A Universal Surrogate Reporter for Efficient Enrichment of CRISPR/Cas9-Mediated Homology-Directed Repair in Mammalian Cells

CRISPR/Cas9-mediated homology-directed repair (HDR) can be leveraged to precisely engineer mammalian genomes. However, the inherently low efficiency of HDR often hampers to identify the desired modified cells. Here, we developed a novel universal surrogate reporter system that efficiently enriches f...

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Detalles Bibliográficos
Autores principales: Yan, Nana, Sun, Yongsen, Fang, Yuanyuan, Deng, Jingrong, Mu, Lu, Xu, Kun, Mymryk, Joe S., Zhang, Zhiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970138/
https://www.ncbi.nlm.nih.gov/pubmed/31955009
http://dx.doi.org/10.1016/j.omtn.2019.12.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970138/
https://www.ncbi.nlm.nih.gov/pubmed/31955009
http://dx.doi.org/10.1016/j.omtn.2019.12.021

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