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IL-6 and G-CSF production resulting from lung cancer in an HIV patient

Increasing reports have noted an increased prevalence of lung cancer in human immunodeficiency virus (HIV)-positive patients with poor prognosis. A 51-year-old HIV-positive man was diagnosed with stage IV squamous cell lung cancer. He had high grade spike intermittent fever and persistent elevation...

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Autores principales: Kawakami, Naoki, Namkoong, Ho, Masaki, Katsunori, Kurebayashi, Yutaka, Shimoda, Masayuki, Kotani, Hiroshi, Fujiwara, Hiroshi, Hasegawa, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970163/
https://www.ncbi.nlm.nih.gov/pubmed/31988848
http://dx.doi.org/10.1016/j.idcr.2020.e00693
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author Kawakami, Naoki
Namkoong, Ho
Masaki, Katsunori
Kurebayashi, Yutaka
Shimoda, Masayuki
Kotani, Hiroshi
Fujiwara, Hiroshi
Hasegawa, Naoki
author_facet Kawakami, Naoki
Namkoong, Ho
Masaki, Katsunori
Kurebayashi, Yutaka
Shimoda, Masayuki
Kotani, Hiroshi
Fujiwara, Hiroshi
Hasegawa, Naoki
author_sort Kawakami, Naoki
collection PubMed
description Increasing reports have noted an increased prevalence of lung cancer in human immunodeficiency virus (HIV)-positive patients with poor prognosis. A 51-year-old HIV-positive man was diagnosed with stage IV squamous cell lung cancer. He had high grade spike intermittent fever and persistent elevation of the white blood cell count as well as C-reactive protein (CRP) levels. Although we suspected opportunistic infections, we did not detect any infection. The autopsy showed positive immunostaining for Interleukin-6 (IL-6) in plasma cells of the stromal regions and G-CSF in tumor cells, which were considered responsible for his significant tumor fever, leukocytosis and high titers of CRP. This case report highlights the need to consider cytokine-producing tumor as a differential diagnosis of fever and high inflammatory status in HIV-positive cancer patients.
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spelling pubmed-69701632020-01-27 IL-6 and G-CSF production resulting from lung cancer in an HIV patient Kawakami, Naoki Namkoong, Ho Masaki, Katsunori Kurebayashi, Yutaka Shimoda, Masayuki Kotani, Hiroshi Fujiwara, Hiroshi Hasegawa, Naoki IDCases Article Increasing reports have noted an increased prevalence of lung cancer in human immunodeficiency virus (HIV)-positive patients with poor prognosis. A 51-year-old HIV-positive man was diagnosed with stage IV squamous cell lung cancer. He had high grade spike intermittent fever and persistent elevation of the white blood cell count as well as C-reactive protein (CRP) levels. Although we suspected opportunistic infections, we did not detect any infection. The autopsy showed positive immunostaining for Interleukin-6 (IL-6) in plasma cells of the stromal regions and G-CSF in tumor cells, which were considered responsible for his significant tumor fever, leukocytosis and high titers of CRP. This case report highlights the need to consider cytokine-producing tumor as a differential diagnosis of fever and high inflammatory status in HIV-positive cancer patients. Elsevier 2020-01-09 /pmc/articles/PMC6970163/ /pubmed/31988848 http://dx.doi.org/10.1016/j.idcr.2020.e00693 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kawakami, Naoki
Namkoong, Ho
Masaki, Katsunori
Kurebayashi, Yutaka
Shimoda, Masayuki
Kotani, Hiroshi
Fujiwara, Hiroshi
Hasegawa, Naoki
IL-6 and G-CSF production resulting from lung cancer in an HIV patient
title IL-6 and G-CSF production resulting from lung cancer in an HIV patient
title_full IL-6 and G-CSF production resulting from lung cancer in an HIV patient
title_fullStr IL-6 and G-CSF production resulting from lung cancer in an HIV patient
title_full_unstemmed IL-6 and G-CSF production resulting from lung cancer in an HIV patient
title_short IL-6 and G-CSF production resulting from lung cancer in an HIV patient
title_sort il-6 and g-csf production resulting from lung cancer in an hiv patient
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970163/
https://www.ncbi.nlm.nih.gov/pubmed/31988848
http://dx.doi.org/10.1016/j.idcr.2020.e00693
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