Cargando…

The serum concentration of βCGRP is novel marker for type 1 diabetes

OBJECTIVE: Dysregulation of neuropeptides, such as calcitonin gene-related peptide (CGRP) is thought to play significant roles in diabetes. In the present study, we investigated the importance of beta-calcitonin gene related peptide (βCGRP, CALCB) in the development of type 1 diabetes (T1D). METHODS...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Yong, Lin, Yunfeng, Wang, Jingwen, Guo, Xinxin, Guo, Yujia, Dong, Feng, Gao, Feng, Liu, Qicai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970168/
https://www.ncbi.nlm.nih.gov/pubmed/31989054
http://dx.doi.org/10.1016/j.heliyon.2020.e03223
_version_ 1783489461486616576
author Chen, Yong
Lin, Yunfeng
Wang, Jingwen
Guo, Xinxin
Guo, Yujia
Dong, Feng
Gao, Feng
Liu, Qicai
author_facet Chen, Yong
Lin, Yunfeng
Wang, Jingwen
Guo, Xinxin
Guo, Yujia
Dong, Feng
Gao, Feng
Liu, Qicai
author_sort Chen, Yong
collection PubMed
description OBJECTIVE: Dysregulation of neuropeptides, such as calcitonin gene-related peptide (CGRP) is thought to play significant roles in diabetes. In the present study, we investigated the importance of beta-calcitonin gene related peptide (βCGRP, CALCB) in the development of type 1 diabetes (T1D). METHODS: There were fifty-eight patients with T1D and 320 age and gender-matched healthy controls in Chinese Han population were included, the genotypes of CALCB were analyzed by direct sequencing and the clinicopathologic parameters of patients were also evaluated. RESULTS: Among the SNPs genotyped, the C allele of CALCB_rs3829220 T (c.224G + 846) and rs382922 C (c.224G + 848) were positively associated with T1D (OR = 2.67 and 3.42, respectively). Serum βCGRP of patients is 1.58 times higher compare to normal control. Immunohistochemistry analysis revealed βCGRP expression in the infiltrating lymphocytes of pancreas from T1D mice as compared to normal control. CONCLUSION: Our findings indicate that the presence of βCGRP is a probable molecular basis for the initial events triggered in T1D.
format Online
Article
Text
id pubmed-6970168
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-69701682020-01-27 The serum concentration of βCGRP is novel marker for type 1 diabetes Chen, Yong Lin, Yunfeng Wang, Jingwen Guo, Xinxin Guo, Yujia Dong, Feng Gao, Feng Liu, Qicai Heliyon Article OBJECTIVE: Dysregulation of neuropeptides, such as calcitonin gene-related peptide (CGRP) is thought to play significant roles in diabetes. In the present study, we investigated the importance of beta-calcitonin gene related peptide (βCGRP, CALCB) in the development of type 1 diabetes (T1D). METHODS: There were fifty-eight patients with T1D and 320 age and gender-matched healthy controls in Chinese Han population were included, the genotypes of CALCB were analyzed by direct sequencing and the clinicopathologic parameters of patients were also evaluated. RESULTS: Among the SNPs genotyped, the C allele of CALCB_rs3829220 T (c.224G + 846) and rs382922 C (c.224G + 848) were positively associated with T1D (OR = 2.67 and 3.42, respectively). Serum βCGRP of patients is 1.58 times higher compare to normal control. Immunohistochemistry analysis revealed βCGRP expression in the infiltrating lymphocytes of pancreas from T1D mice as compared to normal control. CONCLUSION: Our findings indicate that the presence of βCGRP is a probable molecular basis for the initial events triggered in T1D. Elsevier 2020-01-16 /pmc/articles/PMC6970168/ /pubmed/31989054 http://dx.doi.org/10.1016/j.heliyon.2020.e03223 Text en © 2020 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Chen, Yong
Lin, Yunfeng
Wang, Jingwen
Guo, Xinxin
Guo, Yujia
Dong, Feng
Gao, Feng
Liu, Qicai
The serum concentration of βCGRP is novel marker for type 1 diabetes
title The serum concentration of βCGRP is novel marker for type 1 diabetes
title_full The serum concentration of βCGRP is novel marker for type 1 diabetes
title_fullStr The serum concentration of βCGRP is novel marker for type 1 diabetes
title_full_unstemmed The serum concentration of βCGRP is novel marker for type 1 diabetes
title_short The serum concentration of βCGRP is novel marker for type 1 diabetes
title_sort serum concentration of βcgrp is novel marker for type 1 diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970168/
https://www.ncbi.nlm.nih.gov/pubmed/31989054
http://dx.doi.org/10.1016/j.heliyon.2020.e03223
work_keys_str_mv AT chenyong theserumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT linyunfeng theserumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT wangjingwen theserumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT guoxinxin theserumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT guoyujia theserumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT dongfeng theserumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT gaofeng theserumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT liuqicai theserumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT chenyong serumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT linyunfeng serumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT wangjingwen serumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT guoxinxin serumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT guoyujia serumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT dongfeng serumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT gaofeng serumconcentrationofbcgrpisnovelmarkerfortype1diabetes
AT liuqicai serumconcentrationofbcgrpisnovelmarkerfortype1diabetes