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The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice

Abnormal protein homeostasis (proteostasis), dysfunctional mitochondria, and aberrant redox signalling are often associated in neurodegenerative disorders, such as Huntington's (HD), Alzheimer's and Parkinson's diseases. It remains incompletely understood, however, how changes in redo...

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Detalles Bibliográficos
Autores principales: Pinho, Brígida R., Duarte, Ana I., Canas, Paula M., Moreira, Paula I., Murphy, Michael P., Oliveira, Jorge M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970224/
https://www.ncbi.nlm.nih.gov/pubmed/31751762
http://dx.doi.org/10.1016/j.freeradbiomed.2019.11.021