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Symptomatic CNS Radiation Necrosis Requiring Neurosurgical Resection During Treatment with Lorlatinib in ALK-Rearranged NSCLC: A Report of Two Cases

Central nervous system (CNS) metastasis carries a significant morbidity and mortality in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). Next-generation ALK tyrosine kinase inhibitors (TKIs) are highly CNS-penetrant and have demonstrated remarkable intracranial activi...

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Detalles Bibliográficos
Autores principales:	Zhu, Viola W, Nagasaka, Misako, Kubota, Takafumi, Raval, Kunil, Robinette, Natasha, Armas, Octavio, Al-Holou, Wajd, Ou, Sai-Hong Ignatius
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Case Series
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970251/ https://www.ncbi.nlm.nih.gov/pubmed/32021525 http://dx.doi.org/10.2147/LCTT.S224991

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