Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca(2+) Handling After Pressure Overload

BACKGROUND: Orai1 is a critical ion channel subunit, best recognized as a mediator of store-operated Ca(2+) entry (SOCE) in nonexcitable cells. SOCE has recently emerged as a key contributor of cardiac hypertrophy and heart failure but the relevance of Orai1 is still unclear. METHODS: To test the ro...

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Detalles Bibliográficos
Autores principales: Bartoli, Fiona, Bailey, Marc A., Rode, Baptiste, Mateo, Philippe, Antigny, Fabrice, Bedouet, Kaveen, Gerbaud, Pascale, Gosain, Rajendra, Plante, Jeffrey, Norman, Katherine, Gomez, Susana, Lefebvre, Florence, Rucker-Martin, Catherine, Ainscough, Justin F.X., Kearney, Mark T., Bruns, Alexander-Francisco, Shi, Jian, Appleby, Hollie L., Young, Richard S., Shawer, Heba M., Debant, Marjolaine, Gomez, Ana-Maria, Beech, David J., Foster, Richard, Benitah, Jean-Pierre, Sabourin, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970549/
https://www.ncbi.nlm.nih.gov/pubmed/31906693
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970549/
https://www.ncbi.nlm.nih.gov/pubmed/31906693
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038891

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