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Long-term distress in older patients with cancer: a longitudinal cohort study

BACKGROUND: Receiving a cancer diagnosis can be a major life event which causes distress even years after primary treatment. AIM: To examine the prevalence of distress in older patients with cancer (OPCs) up until 5 years post-diagnosis, and identify predictors present at time of diagnosis. Results...

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Autores principales: Dauphin, Stephanie, Jansen, Leontien, De Burghgraeve, Tine, Deckx, Laura, Buntinx, Frank, van den Akker, Marjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal College of General Practitioners 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970590/
https://www.ncbi.nlm.nih.gov/pubmed/31581109
http://dx.doi.org/10.3399/bjgpopen19X101658
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author Dauphin, Stephanie
Jansen, Leontien
De Burghgraeve, Tine
Deckx, Laura
Buntinx, Frank
van den Akker, Marjan
author_facet Dauphin, Stephanie
Jansen, Leontien
De Burghgraeve, Tine
Deckx, Laura
Buntinx, Frank
van den Akker, Marjan
author_sort Dauphin, Stephanie
collection PubMed
description BACKGROUND: Receiving a cancer diagnosis can be a major life event which causes distress even years after primary treatment. AIM: To examine the prevalence of distress in older patients with cancer (OPCs) up until 5 years post-diagnosis, and identify predictors present at time of diagnosis. Results are compared with reference groups of middle-aged patients with cancer (MPCs) and older patients without a cancer diagnosis (OPs). DESIGN & SETTING: OPCs, MPCs, and OPs participated in a longitudinal cohort study in Belgium and the Netherlands by filling in questionnaires at designated time points from 2010–2019. METHOD: Data from 541 patients were analysed using multivariable logistic regression analyses. RESULTS: At baseline, 40% of OPCs, 37% of MPCs, and 17% of OPs reported distress. After 5 years, 35% of OPCs, 23% of MPCs, and 25% of OPs reported distress. No significant predictors for long-term distress in OPCs and OPs were found. For MPCs, it was found that baseline distress (odds ratio [OR] 2.94; 95% confidence intervals [CI] = 1.40 to 6.19) and baseline fatigue (OR 4.71; 95% CI = 1.81 to 12.31) predicted long-term distress. CONCLUSION: Distress is an important problem for people with cancer, with peaks at different moments after diagnosis. Feelings of distress are present shortly after diagnosis but they decrease quickly for the majority of patients. In the long term, however, OPCs in particular appear to be most at risk for distress. This warrants extra attention from primary healthcare professionals, such as GPs who are often patients’ first medical contact point. More research into risk factors occurring later in an illness trajectory might shed more light on predictors for development of long-term distress.
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spelling pubmed-69705902020-01-29 Long-term distress in older patients with cancer: a longitudinal cohort study Dauphin, Stephanie Jansen, Leontien De Burghgraeve, Tine Deckx, Laura Buntinx, Frank van den Akker, Marjan BJGP Open Research BACKGROUND: Receiving a cancer diagnosis can be a major life event which causes distress even years after primary treatment. AIM: To examine the prevalence of distress in older patients with cancer (OPCs) up until 5 years post-diagnosis, and identify predictors present at time of diagnosis. Results are compared with reference groups of middle-aged patients with cancer (MPCs) and older patients without a cancer diagnosis (OPs). DESIGN & SETTING: OPCs, MPCs, and OPs participated in a longitudinal cohort study in Belgium and the Netherlands by filling in questionnaires at designated time points from 2010–2019. METHOD: Data from 541 patients were analysed using multivariable logistic regression analyses. RESULTS: At baseline, 40% of OPCs, 37% of MPCs, and 17% of OPs reported distress. After 5 years, 35% of OPCs, 23% of MPCs, and 25% of OPs reported distress. No significant predictors for long-term distress in OPCs and OPs were found. For MPCs, it was found that baseline distress (odds ratio [OR] 2.94; 95% confidence intervals [CI] = 1.40 to 6.19) and baseline fatigue (OR 4.71; 95% CI = 1.81 to 12.31) predicted long-term distress. CONCLUSION: Distress is an important problem for people with cancer, with peaks at different moments after diagnosis. Feelings of distress are present shortly after diagnosis but they decrease quickly for the majority of patients. In the long term, however, OPCs in particular appear to be most at risk for distress. This warrants extra attention from primary healthcare professionals, such as GPs who are often patients’ first medical contact point. More research into risk factors occurring later in an illness trajectory might shed more light on predictors for development of long-term distress. Royal College of General Practitioners 2019-09-04 /pmc/articles/PMC6970590/ /pubmed/31581109 http://dx.doi.org/10.3399/bjgpopen19X101658 Text en Copyright © 2019, The Authors https://creativecommons.org/licenses/by/4.0/ This article is Open Access: CC BY license (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Research
Dauphin, Stephanie
Jansen, Leontien
De Burghgraeve, Tine
Deckx, Laura
Buntinx, Frank
van den Akker, Marjan
Long-term distress in older patients with cancer: a longitudinal cohort study
title Long-term distress in older patients with cancer: a longitudinal cohort study
title_full Long-term distress in older patients with cancer: a longitudinal cohort study
title_fullStr Long-term distress in older patients with cancer: a longitudinal cohort study
title_full_unstemmed Long-term distress in older patients with cancer: a longitudinal cohort study
title_short Long-term distress in older patients with cancer: a longitudinal cohort study
title_sort long-term distress in older patients with cancer: a longitudinal cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970590/
https://www.ncbi.nlm.nih.gov/pubmed/31581109
http://dx.doi.org/10.3399/bjgpopen19X101658
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