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Enhancing Betulinic Acid Dissolution Rate and Improving Antitumor Activity via Nanosuspension Constructed by Anti-Solvent Technique

PURPOSE: The aim of this study was to prepare and evaluate betulinic acid nanosuspension (BA-NS) for new drug delivery to enhance its solubility and in vitro anti-tumor activity. METHODS: BA-NS was formulated by an anti-solvent precipitation method using the Box-Behnken design (BBD). Particle size (...

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Detalles Bibliográficos
Autores principales:	Li, Shuqi, Zhang, Jie, Fang, Yuqi, Yi, Jun, Lu, Zhufen, Chen, Yanzhong, Guo, Bohong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970624/ https://www.ncbi.nlm.nih.gov/pubmed/32021108 http://dx.doi.org/10.2147/DDDT.S233851

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