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The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis
The prognostic role of Human leukocyte antigen class I (HLA- I) in gastrointestinal cancers has been remained controversial. We performed a meta-analysis to determine the role of classical HLA-I in predicting survival of patients. In addition, the relationship between HLA- I and some clinicopatholog...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970991/ https://www.ncbi.nlm.nih.gov/pubmed/31959894 http://dx.doi.org/10.1038/s41598-020-57582-x |
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author | Najafimehr, Hadis Hajizadeh, Nastaran Nazemalhosseini-Mojarad, Ehsan Pourhoseingholi, Mohamad Amin Abdollahpour-Alitappeh, Meghdad Ashtari, Sara Zali, Mohammad Reza |
author_facet | Najafimehr, Hadis Hajizadeh, Nastaran Nazemalhosseini-Mojarad, Ehsan Pourhoseingholi, Mohamad Amin Abdollahpour-Alitappeh, Meghdad Ashtari, Sara Zali, Mohammad Reza |
author_sort | Najafimehr, Hadis |
collection | PubMed |
description | The prognostic role of Human leukocyte antigen class I (HLA- I) in gastrointestinal cancers has been remained controversial. We performed a meta-analysis to determine the role of classical HLA-I in predicting survival of patients. In addition, the relationship between HLA- I and some clinicopathological factors was evaluated. Published studies investigated HLA-I expression effect on gastrointestinal cancers were evaluated to determine association between HLA- I and overall survival (OS) and recurrence-free survival (RFS) in patients. The used effect sizes were hazard ratio (HR) and Odds ratio (OR) with 95% confidence interval (CI). A total of ten studies included 1307 patients were analyzed. The pooled results revealed that HLA- I overexpression was positively related to OS (HR: 0.72; 95% CI: 0.53–0.96) and demonstrated little association for RFS (HR: 0.70; 95% CI: 0.46–1.08). HLA-I overexpression is negative associated with poorer differentiation of tumor (OR: 0.53; 95% CI (0.43–0.81) and also higher stages of cancer (OR: 0.29; 95% CI (0.13–0.64). HLA- I overexpression was related to a better prognosis on OS and probably had little impact on RFS. |
format | Online Article Text |
id | pubmed-6970991 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69709912020-01-27 The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis Najafimehr, Hadis Hajizadeh, Nastaran Nazemalhosseini-Mojarad, Ehsan Pourhoseingholi, Mohamad Amin Abdollahpour-Alitappeh, Meghdad Ashtari, Sara Zali, Mohammad Reza Sci Rep Article The prognostic role of Human leukocyte antigen class I (HLA- I) in gastrointestinal cancers has been remained controversial. We performed a meta-analysis to determine the role of classical HLA-I in predicting survival of patients. In addition, the relationship between HLA- I and some clinicopathological factors was evaluated. Published studies investigated HLA-I expression effect on gastrointestinal cancers were evaluated to determine association between HLA- I and overall survival (OS) and recurrence-free survival (RFS) in patients. The used effect sizes were hazard ratio (HR) and Odds ratio (OR) with 95% confidence interval (CI). A total of ten studies included 1307 patients were analyzed. The pooled results revealed that HLA- I overexpression was positively related to OS (HR: 0.72; 95% CI: 0.53–0.96) and demonstrated little association for RFS (HR: 0.70; 95% CI: 0.46–1.08). HLA-I overexpression is negative associated with poorer differentiation of tumor (OR: 0.53; 95% CI (0.43–0.81) and also higher stages of cancer (OR: 0.29; 95% CI (0.13–0.64). HLA- I overexpression was related to a better prognosis on OS and probably had little impact on RFS. Nature Publishing Group UK 2020-01-20 /pmc/articles/PMC6970991/ /pubmed/31959894 http://dx.doi.org/10.1038/s41598-020-57582-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Najafimehr, Hadis Hajizadeh, Nastaran Nazemalhosseini-Mojarad, Ehsan Pourhoseingholi, Mohamad Amin Abdollahpour-Alitappeh, Meghdad Ashtari, Sara Zali, Mohammad Reza The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis |
title | The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis |
title_full | The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis |
title_fullStr | The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis |
title_full_unstemmed | The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis |
title_short | The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis |
title_sort | role of human leukocyte antigen class i on patient survival in gastrointestinal cancers: a systematic review and meta- analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970991/ https://www.ncbi.nlm.nih.gov/pubmed/31959894 http://dx.doi.org/10.1038/s41598-020-57582-x |
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