Cargando…

The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis

The prognostic role of Human leukocyte antigen class I (HLA- I) in gastrointestinal cancers has been remained controversial. We performed a meta-analysis to determine the role of classical HLA-I in predicting survival of patients. In addition, the relationship between HLA- I and some clinicopatholog...

Descripción completa

Detalles Bibliográficos
Autores principales: Najafimehr, Hadis, Hajizadeh, Nastaran, Nazemalhosseini-Mojarad, Ehsan, Pourhoseingholi, Mohamad Amin, Abdollahpour-Alitappeh, Meghdad, Ashtari, Sara, Zali, Mohammad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970991/
https://www.ncbi.nlm.nih.gov/pubmed/31959894
http://dx.doi.org/10.1038/s41598-020-57582-x
_version_ 1783489623881678848
author Najafimehr, Hadis
Hajizadeh, Nastaran
Nazemalhosseini-Mojarad, Ehsan
Pourhoseingholi, Mohamad Amin
Abdollahpour-Alitappeh, Meghdad
Ashtari, Sara
Zali, Mohammad Reza
author_facet Najafimehr, Hadis
Hajizadeh, Nastaran
Nazemalhosseini-Mojarad, Ehsan
Pourhoseingholi, Mohamad Amin
Abdollahpour-Alitappeh, Meghdad
Ashtari, Sara
Zali, Mohammad Reza
author_sort Najafimehr, Hadis
collection PubMed
description The prognostic role of Human leukocyte antigen class I (HLA- I) in gastrointestinal cancers has been remained controversial. We performed a meta-analysis to determine the role of classical HLA-I in predicting survival of patients. In addition, the relationship between HLA- I and some clinicopathological factors was evaluated. Published studies investigated HLA-I expression effect on gastrointestinal cancers were evaluated to determine association between HLA- I and overall survival (OS) and recurrence-free survival (RFS) in patients. The used effect sizes were hazard ratio (HR) and Odds ratio (OR) with 95% confidence interval (CI). A total of ten studies included 1307 patients were analyzed. The pooled results revealed that HLA- I overexpression was positively related to OS (HR: 0.72; 95% CI: 0.53–0.96) and demonstrated little association for RFS (HR: 0.70; 95% CI: 0.46–1.08). HLA-I overexpression is negative associated with poorer differentiation of tumor (OR: 0.53; 95% CI (0.43–0.81) and also higher stages of cancer (OR: 0.29; 95% CI (0.13–0.64). HLA- I overexpression was related to a better prognosis on OS and probably had little impact on RFS.
format Online
Article
Text
id pubmed-6970991
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-69709912020-01-27 The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis Najafimehr, Hadis Hajizadeh, Nastaran Nazemalhosseini-Mojarad, Ehsan Pourhoseingholi, Mohamad Amin Abdollahpour-Alitappeh, Meghdad Ashtari, Sara Zali, Mohammad Reza Sci Rep Article The prognostic role of Human leukocyte antigen class I (HLA- I) in gastrointestinal cancers has been remained controversial. We performed a meta-analysis to determine the role of classical HLA-I in predicting survival of patients. In addition, the relationship between HLA- I and some clinicopathological factors was evaluated. Published studies investigated HLA-I expression effect on gastrointestinal cancers were evaluated to determine association between HLA- I and overall survival (OS) and recurrence-free survival (RFS) in patients. The used effect sizes were hazard ratio (HR) and Odds ratio (OR) with 95% confidence interval (CI). A total of ten studies included 1307 patients were analyzed. The pooled results revealed that HLA- I overexpression was positively related to OS (HR: 0.72; 95% CI: 0.53–0.96) and demonstrated little association for RFS (HR: 0.70; 95% CI: 0.46–1.08). HLA-I overexpression is negative associated with poorer differentiation of tumor (OR: 0.53; 95% CI (0.43–0.81) and also higher stages of cancer (OR: 0.29; 95% CI (0.13–0.64). HLA- I overexpression was related to a better prognosis on OS and probably had little impact on RFS. Nature Publishing Group UK 2020-01-20 /pmc/articles/PMC6970991/ /pubmed/31959894 http://dx.doi.org/10.1038/s41598-020-57582-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Najafimehr, Hadis
Hajizadeh, Nastaran
Nazemalhosseini-Mojarad, Ehsan
Pourhoseingholi, Mohamad Amin
Abdollahpour-Alitappeh, Meghdad
Ashtari, Sara
Zali, Mohammad Reza
The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis
title The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis
title_full The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis
title_fullStr The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis
title_full_unstemmed The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis
title_short The role of Human leukocyte antigen class I on patient survival in Gastrointestinal cancers: a systematic review and meta- analysis
title_sort role of human leukocyte antigen class i on patient survival in gastrointestinal cancers: a systematic review and meta- analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970991/
https://www.ncbi.nlm.nih.gov/pubmed/31959894
http://dx.doi.org/10.1038/s41598-020-57582-x
work_keys_str_mv AT najafimehrhadis theroleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT hajizadehnastaran theroleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT nazemalhosseinimojaradehsan theroleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT pourhoseingholimohamadamin theroleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT abdollahpouralitappehmeghdad theroleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT ashtarisara theroleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT zalimohammadreza theroleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT najafimehrhadis roleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT hajizadehnastaran roleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT nazemalhosseinimojaradehsan roleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT pourhoseingholimohamadamin roleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT abdollahpouralitappehmeghdad roleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT ashtarisara roleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis
AT zalimohammadreza roleofhumanleukocyteantigenclassionpatientsurvivalingastrointestinalcancersasystematicreviewandmetaanalysis