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TAK-242 ameliorates contact dermatitis exacerbated by IL-36 receptor antagonist deficiency

Loss-of-function mutations in IL36RN cause generalized pustular psoriasis (GPP), which is characterized by neutrophil-infiltrated lesions. Neutrophils are important during contact hypersensitivity in mice. However, it has never been determined whether interleukin-36 receptor antagonist (IL-36Ra) def...

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Detalles Bibliográficos
Autores principales:	Fukushima, Hidehiko, Iwata, Yohei, Watanabe, Soichiro, Saito, Kenta, Tanaka, Yoshihito, Hasegawa, Yurie, Akiyama, Masashi, Sugiura, Kazumitsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971010/ https://www.ncbi.nlm.nih.gov/pubmed/31959814 http://dx.doi.org/10.1038/s41598-020-57550-5

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