Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling

Infection with transmissible gastroenteritis virus (TGEV) has been associated with villous atrophy within 48 h, which seriously disrupts intestinal homeostasis. However, the underlying mechanisms remain elusive. In this study, we found that TGEV infection severely disrupted intestinal homeostasis vi...

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Detalles Bibliográficos
Autores principales: Wu, Aimin, Yu, Bing, Zhang, Keying, Xu, Zhiwen, Wu, De, He, Jun, Luo, Junqiu, Luo, Yuheng, Yu, Jie, Zheng, Ping, Che, Lianqiang, Mao, Xiangbing, Huang, Zhiqing, Wang, Lan, Zhao, Jun, Chen, Daiwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971083/
https://www.ncbi.nlm.nih.gov/pubmed/31959773
http://dx.doi.org/10.1038/s41419-020-2233-6

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