Targeting BET Proteins With a PROTAC Molecule Elicits Potent Anticancer Activity in HCC Cells

Background and Aim: Bromodomain and extraterminal domain (BET) family proteins are epigenetic regulators involved in human malignances. Targeting BET proteins for degradation using proteolysis-targeting chimera (PROTAC) recently has drawn increasing attention in the field of cancer therapeutics. BET...

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Detalles Bibliográficos
Autores principales: Zhang, Huapeng, Li, Gongquan, Zhang, Yi, Shi, Jihua, Yan, Bing, Tang, Hongwei, Chen, Sanyang, Zhang, Jiakai, Wen, Peihao, Wang, Zhihui, Pang, Chun, Li, Jie, Guo, Wenzhi, Zhang, Shuijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971110/
https://www.ncbi.nlm.nih.gov/pubmed/31993368
http://dx.doi.org/10.3389/fonc.2019.01471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971110/
https://www.ncbi.nlm.nih.gov/pubmed/31993368
http://dx.doi.org/10.3389/fonc.2019.01471

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