Cargando…

Rhodococcus equi Joint Sepsis and Osteomyelitis Is Associated With a Grave Prognosis in Foals

The most common pathologic manifestation of Rhodococcus equi, a gram-positive, facultative intracellular bacterium, is pyogranulomatous pneumonia in foals and weanlings. Hematogenous spread of bacteria may subsequently occur, resulting in joint sepsis, osteomyelitis, or subcutaneous abscessation. Me...

Descripción completa

Detalles Bibliográficos
Autores principales: Ruocco, Nicholas A., Luedke, Lauren K., Fortier, Lisa A., Ducharme, Norm G., Reesink, Heidi L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971166/
https://www.ncbi.nlm.nih.gov/pubmed/31993449
http://dx.doi.org/10.3389/fvets.2019.00503
_version_ 1783489665313013760
author Ruocco, Nicholas A.
Luedke, Lauren K.
Fortier, Lisa A.
Ducharme, Norm G.
Reesink, Heidi L.
author_facet Ruocco, Nicholas A.
Luedke, Lauren K.
Fortier, Lisa A.
Ducharme, Norm G.
Reesink, Heidi L.
author_sort Ruocco, Nicholas A.
collection PubMed
description The most common pathologic manifestation of Rhodococcus equi, a gram-positive, facultative intracellular bacterium, is pyogranulomatous pneumonia in foals and weanlings. Hematogenous spread of bacteria may subsequently occur, resulting in joint sepsis, osteomyelitis, or subcutaneous abscessation. Medical records from horses presenting to the Cornell University Equine Hospital from 1998 to 2018 were reviewed for cases diagnosed with R. equi joint and/or bone infection, and information about case progression and outcome were analyzed. We hypothesized that, despite advances in diagnostic imaging, antimicrobials and antimicrobial delivery methods, the prognosis for R. equi joint sepsis and osteomyelitis remains grave for athletic activity and poor for survival. The 12 cases that met the review criteria had a mortality rate of 84% (10/12), with one case lost to follow up after discharge and one case discharged with a grave prognosis for athleticism.
format Online
Article
Text
id pubmed-6971166
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-69711662020-01-28 Rhodococcus equi Joint Sepsis and Osteomyelitis Is Associated With a Grave Prognosis in Foals Ruocco, Nicholas A. Luedke, Lauren K. Fortier, Lisa A. Ducharme, Norm G. Reesink, Heidi L. Front Vet Sci Veterinary Science The most common pathologic manifestation of Rhodococcus equi, a gram-positive, facultative intracellular bacterium, is pyogranulomatous pneumonia in foals and weanlings. Hematogenous spread of bacteria may subsequently occur, resulting in joint sepsis, osteomyelitis, or subcutaneous abscessation. Medical records from horses presenting to the Cornell University Equine Hospital from 1998 to 2018 were reviewed for cases diagnosed with R. equi joint and/or bone infection, and information about case progression and outcome were analyzed. We hypothesized that, despite advances in diagnostic imaging, antimicrobials and antimicrobial delivery methods, the prognosis for R. equi joint sepsis and osteomyelitis remains grave for athletic activity and poor for survival. The 12 cases that met the review criteria had a mortality rate of 84% (10/12), with one case lost to follow up after discharge and one case discharged with a grave prognosis for athleticism. Frontiers Media S.A. 2020-01-14 /pmc/articles/PMC6971166/ /pubmed/31993449 http://dx.doi.org/10.3389/fvets.2019.00503 Text en Copyright © 2020 Ruocco, Luedke, Fortier, Ducharme and Reesink. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Ruocco, Nicholas A.
Luedke, Lauren K.
Fortier, Lisa A.
Ducharme, Norm G.
Reesink, Heidi L.
Rhodococcus equi Joint Sepsis and Osteomyelitis Is Associated With a Grave Prognosis in Foals
title Rhodococcus equi Joint Sepsis and Osteomyelitis Is Associated With a Grave Prognosis in Foals
title_full Rhodococcus equi Joint Sepsis and Osteomyelitis Is Associated With a Grave Prognosis in Foals
title_fullStr Rhodococcus equi Joint Sepsis and Osteomyelitis Is Associated With a Grave Prognosis in Foals
title_full_unstemmed Rhodococcus equi Joint Sepsis and Osteomyelitis Is Associated With a Grave Prognosis in Foals
title_short Rhodococcus equi Joint Sepsis and Osteomyelitis Is Associated With a Grave Prognosis in Foals
title_sort rhodococcus equi joint sepsis and osteomyelitis is associated with a grave prognosis in foals
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971166/
https://www.ncbi.nlm.nih.gov/pubmed/31993449
http://dx.doi.org/10.3389/fvets.2019.00503
work_keys_str_mv AT ruocconicholasa rhodococcusequijointsepsisandosteomyelitisisassociatedwithagraveprognosisinfoals
AT luedkelaurenk rhodococcusequijointsepsisandosteomyelitisisassociatedwithagraveprognosisinfoals
AT fortierlisaa rhodococcusequijointsepsisandosteomyelitisisassociatedwithagraveprognosisinfoals
AT ducharmenormg rhodococcusequijointsepsisandosteomyelitisisassociatedwithagraveprognosisinfoals
AT reesinkheidil rhodococcusequijointsepsisandosteomyelitisisassociatedwithagraveprognosisinfoals