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Astrocytes and Microglia Are Resistant to NAD(+)-Mediated Cell Death Along the ARTC2/P2X7 Axis

ADP-ribosylation of the P2X7k splice variant on mouse T cells by Ecto-ADP-ribosyltransferase ARTC2.2 in response to its substrate extracellular nicotinamide adenine dinucleotide (NAD(+)) triggers cell death. Since NAD(+) is released as a danger signal during tissue damage, this NAD(+)-induced cell d...

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Detalles Bibliográficos
Autores principales:	Rissiek, Björn, Stabernack, Joschi, Cordes, Maike, Duan, Yinghui, Behr, Sarah, Menzel, Stephan, Magnus, Tim, Koch-Nolte, Friedrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971201/ https://www.ncbi.nlm.nih.gov/pubmed/32009900 http://dx.doi.org/10.3389/fnmol.2019.00330

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