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Somatic Mosaicism of IDH1 R132H Predisposes to Anaplastic Astrocytoma: A Case of Two Siblings

Anaplastic astrocytomas are aggressive glial cancers that present poor prognosis and high recurrence. Heterozygous IDH1 R132H mutations are common in adolescent and young adult anaplastic astrocytomas. In a majority of cases, the IDH1 R132H mutation is unique to the tumor, although rare cases of ana...

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Detalles Bibliográficos
Autores principales:	Lee, Sulgi, Kambhampati, Madhuri, Almira-Suarez, M. Isabel, Ho, Cheng-Ying, Panditharatna, Eshini, Berger, Seth I., Turner, Joyce, Van Mater, David, Kilburn, Lindsay, Packer, Roger J., Myseros, John S., Vilain, Eric, Nazarian, Javad, Bornhorst, Miriam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971203/ https://www.ncbi.nlm.nih.gov/pubmed/32010615 http://dx.doi.org/10.3389/fonc.2019.01507

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