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RNA Editing of Serotonin 2C Receptor and Alcohol Intake
Serotonin 2C receptor (5-HT(2)(C)R) belongs to the superfamily of seven transmembrane domain receptors coupled to G proteins (GPCR). It is broadly distributed in the CNS and its expression is relatively high in the limbic system including the amygdala, nucleus accumbens (NAc), hippocampus, and hypot...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971223/ https://www.ncbi.nlm.nih.gov/pubmed/32009879 http://dx.doi.org/10.3389/fnins.2019.01390 |
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author | Tanaka, Masaki Watanabe, Yoshihisa |
author_facet | Tanaka, Masaki Watanabe, Yoshihisa |
author_sort | Tanaka, Masaki |
collection | PubMed |
description | Serotonin 2C receptor (5-HT(2)(C)R) belongs to the superfamily of seven transmembrane domain receptors coupled to G proteins (GPCR). It is broadly distributed in the CNS and its expression is relatively high in the limbic system including the amygdala, nucleus accumbens (NAc), hippocampus, and hypothalamus. Based on its expression patterns and numerous pharmacological studies, 5-HT(2)(C)R is thought to be involved in various brain functions including emotion, appetite, and motor behavior. Here, we review 5-HT(2)(C)R and its relationship with alcohol intake with a particular focus on the involvement of 5-HT(2)(C)R mRNA editing and its association with alcohol preference in mice. RNA editing is a post-transcriptional modification mechanism. In mammals, adenosine is converted to inosine by the deamination enzymes ADAR1 and ADAR2. 5-HT(2)(C)R is the only GPCR subjected to RNA editing within the coding region. It has five editing sites in exon 5 that encode the second intracellular loop. Consequently, three amino acids residues (I156, N158, and I160) of the unedited receptor (INI) may be altered to differently edited isoforms, resulting in a change of receptor activity such as 5-HT potency and G-protein coupling. 5-HT(2)(C)R in the NAc is involved in enhanced alcohol drinking after chronic alcohol exposure and alterations in 5-HT(2)(C)R mRNA editing is important in determining the alcohol preference using different strains of mice and genetically modified mice. RNA editing of this receptor may participate in the development of alcoholism. |
format | Online Article Text |
id | pubmed-6971223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69712232020-02-01 RNA Editing of Serotonin 2C Receptor and Alcohol Intake Tanaka, Masaki Watanabe, Yoshihisa Front Neurosci Neuroscience Serotonin 2C receptor (5-HT(2)(C)R) belongs to the superfamily of seven transmembrane domain receptors coupled to G proteins (GPCR). It is broadly distributed in the CNS and its expression is relatively high in the limbic system including the amygdala, nucleus accumbens (NAc), hippocampus, and hypothalamus. Based on its expression patterns and numerous pharmacological studies, 5-HT(2)(C)R is thought to be involved in various brain functions including emotion, appetite, and motor behavior. Here, we review 5-HT(2)(C)R and its relationship with alcohol intake with a particular focus on the involvement of 5-HT(2)(C)R mRNA editing and its association with alcohol preference in mice. RNA editing is a post-transcriptional modification mechanism. In mammals, adenosine is converted to inosine by the deamination enzymes ADAR1 and ADAR2. 5-HT(2)(C)R is the only GPCR subjected to RNA editing within the coding region. It has five editing sites in exon 5 that encode the second intracellular loop. Consequently, three amino acids residues (I156, N158, and I160) of the unedited receptor (INI) may be altered to differently edited isoforms, resulting in a change of receptor activity such as 5-HT potency and G-protein coupling. 5-HT(2)(C)R in the NAc is involved in enhanced alcohol drinking after chronic alcohol exposure and alterations in 5-HT(2)(C)R mRNA editing is important in determining the alcohol preference using different strains of mice and genetically modified mice. RNA editing of this receptor may participate in the development of alcoholism. Frontiers Media S.A. 2020-01-14 /pmc/articles/PMC6971223/ /pubmed/32009879 http://dx.doi.org/10.3389/fnins.2019.01390 Text en Copyright © 2020 Tanaka and Watanabe. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Tanaka, Masaki Watanabe, Yoshihisa RNA Editing of Serotonin 2C Receptor and Alcohol Intake |
title | RNA Editing of Serotonin 2C Receptor and Alcohol Intake |
title_full | RNA Editing of Serotonin 2C Receptor and Alcohol Intake |
title_fullStr | RNA Editing of Serotonin 2C Receptor and Alcohol Intake |
title_full_unstemmed | RNA Editing of Serotonin 2C Receptor and Alcohol Intake |
title_short | RNA Editing of Serotonin 2C Receptor and Alcohol Intake |
title_sort | rna editing of serotonin 2c receptor and alcohol intake |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971223/ https://www.ncbi.nlm.nih.gov/pubmed/32009879 http://dx.doi.org/10.3389/fnins.2019.01390 |
work_keys_str_mv | AT tanakamasaki rnaeditingofserotonin2creceptorandalcoholintake AT watanabeyoshihisa rnaeditingofserotonin2creceptorandalcoholintake |