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Extracellular NAD(+) enhances PARP-dependent DNA repair capacity independently of CD73 activity

Changes in nicotinamide adenine dinucleotide (NAD(+)) levels that compromise mitochondrial function trigger release of DNA damaging reactive oxygen species. NAD(+) levels also affect DNA repair capacity as NAD(+) is a substrate for PARP-enzymes (mono/poly-ADP-ribosylation) and sirtuins (deacetylatio...

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Detalles Bibliográficos
Autores principales:	Wilk, Anna, Hayat, Faisal, Cunningham, Richard, Li, Jianfeng, Garavaglia, Silvia, Zamani, Leila, Ferraris, Davide M., Sykora, Peter, Andrews, Joel, Clark, Jennifer, Davis, Amanda, Chaloin, Laurent, Rizzi, Menico, Migaud, Marie, Sobol, Robert W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971268/ https://www.ncbi.nlm.nih.gov/pubmed/31959836 http://dx.doi.org/10.1038/s41598-020-57506-9

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