Cargando…

Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome

BACKGROUND AND PURPOSE: Metabolic syndrome (MetS) is a disorder associated with an increased risk of cardiovascular disease. The frequency of each component of MetS in Turner syndrome (TS) subjects is high. An elevated incidence of hearing loss has also been reported in TS. Sensorineural hearing los...

Descripción completa

Detalles Bibliográficos
Autores principales: Álvarez-Nava, Francisco, Racines-Orbe, Marcia, Witt, Julia, Guarderas, Jéssica, Vicuña, Yosselin, Estévez, María, Lanes, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971290/
https://www.ncbi.nlm.nih.gov/pubmed/32021381
http://dx.doi.org/10.2147/TACG.S229828
_version_ 1783489694337597440
author Álvarez-Nava, Francisco
Racines-Orbe, Marcia
Witt, Julia
Guarderas, Jéssica
Vicuña, Yosselin
Estévez, María
Lanes, Roberto
author_facet Álvarez-Nava, Francisco
Racines-Orbe, Marcia
Witt, Julia
Guarderas, Jéssica
Vicuña, Yosselin
Estévez, María
Lanes, Roberto
author_sort Álvarez-Nava, Francisco
collection PubMed
description BACKGROUND AND PURPOSE: Metabolic syndrome (MetS) is a disorder associated with an increased risk of cardiovascular disease. The frequency of each component of MetS in Turner syndrome (TS) subjects is high. An elevated incidence of hearing loss has also been reported in TS. Sensorineural hearing loss (SNHL) affects at least half of young women with TS. The association between MetS and SNHL has not been previously considered in TS. The aim of this study is to evaluate the association between these two conditions. PATIENTS AND METHODS: Cross-sectional anthropometric, cardio-metabolic and audiological data were obtained from a cohort consisting of unrelated TS subjects (>20 years of age; n = 93). Metabolic syndrome was defined according to the International Diabetes Federation criteria. Types and severity of hearing loss were based on the American Speech Hearing Association guidelines. RESULTS: Hearing loss was detected in 74% of ears from adult TS subjects and SNHL was observed in half of our TS subjects. The prevalence of MetS in TS subjects with or without SNHL was 64% and 11%, respectively (P < 0.05). After adjusting for age, MetS was related to a ninefold increase in the odds of SNHL. This odds increased in a stepwise manner as the number of MetS components increased. CONCLUSION: MetS and its individual components were associated factors for SNHL in TS subjects. A reduction in the number and severity of the components of MetS might potentially contribute to decreasing the progression of SNHL at younger ages, but further studies will be needed to explain the underlying pathological mechanism connecting MetS and SNHL.
format Online
Article
Text
id pubmed-6971290
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-69712902020-02-04 Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome Álvarez-Nava, Francisco Racines-Orbe, Marcia Witt, Julia Guarderas, Jéssica Vicuña, Yosselin Estévez, María Lanes, Roberto Appl Clin Genet Original Research BACKGROUND AND PURPOSE: Metabolic syndrome (MetS) is a disorder associated with an increased risk of cardiovascular disease. The frequency of each component of MetS in Turner syndrome (TS) subjects is high. An elevated incidence of hearing loss has also been reported in TS. Sensorineural hearing loss (SNHL) affects at least half of young women with TS. The association between MetS and SNHL has not been previously considered in TS. The aim of this study is to evaluate the association between these two conditions. PATIENTS AND METHODS: Cross-sectional anthropometric, cardio-metabolic and audiological data were obtained from a cohort consisting of unrelated TS subjects (>20 years of age; n = 93). Metabolic syndrome was defined according to the International Diabetes Federation criteria. Types and severity of hearing loss were based on the American Speech Hearing Association guidelines. RESULTS: Hearing loss was detected in 74% of ears from adult TS subjects and SNHL was observed in half of our TS subjects. The prevalence of MetS in TS subjects with or without SNHL was 64% and 11%, respectively (P < 0.05). After adjusting for age, MetS was related to a ninefold increase in the odds of SNHL. This odds increased in a stepwise manner as the number of MetS components increased. CONCLUSION: MetS and its individual components were associated factors for SNHL in TS subjects. A reduction in the number and severity of the components of MetS might potentially contribute to decreasing the progression of SNHL at younger ages, but further studies will be needed to explain the underlying pathological mechanism connecting MetS and SNHL. Dove 2020-01-13 /pmc/articles/PMC6971290/ /pubmed/32021381 http://dx.doi.org/10.2147/TACG.S229828 Text en © 2020 Álvarez-Nava et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Álvarez-Nava, Francisco
Racines-Orbe, Marcia
Witt, Julia
Guarderas, Jéssica
Vicuña, Yosselin
Estévez, María
Lanes, Roberto
Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome
title Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome
title_full Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome
title_fullStr Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome
title_full_unstemmed Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome
title_short Metabolic Syndrome as a Risk Factor for Sensorineural Hearing Loss in Adult Patients with Turner Syndrome
title_sort metabolic syndrome as a risk factor for sensorineural hearing loss in adult patients with turner syndrome
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971290/
https://www.ncbi.nlm.nih.gov/pubmed/32021381
http://dx.doi.org/10.2147/TACG.S229828
work_keys_str_mv AT alvareznavafrancisco metabolicsyndromeasariskfactorforsensorineuralhearinglossinadultpatientswithturnersyndrome
AT racinesorbemarcia metabolicsyndromeasariskfactorforsensorineuralhearinglossinadultpatientswithturnersyndrome
AT wittjulia metabolicsyndromeasariskfactorforsensorineuralhearinglossinadultpatientswithturnersyndrome
AT guarderasjessica metabolicsyndromeasariskfactorforsensorineuralhearinglossinadultpatientswithturnersyndrome
AT vicunayosselin metabolicsyndromeasariskfactorforsensorineuralhearinglossinadultpatientswithturnersyndrome
AT estevezmaria metabolicsyndromeasariskfactorforsensorineuralhearinglossinadultpatientswithturnersyndrome
AT lanesroberto metabolicsyndromeasariskfactorforsensorineuralhearinglossinadultpatientswithturnersyndrome