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A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9

BACKGROUND: Von Willebrand Disease (VWD) is the most common inherited bleeding disorder, caused by quantitative and qualitative changes in von Willebrand factor (VWF). The biology of VWD, studied in canine, porcine, and murine models, differ in species‐specific biology of VWF and the amenability to...

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Detalles Bibliográficos
Autores principales:	Garcia, Jessica, Flood, Veronica H., Haberichter, Sandra L., Fahs, Scot A., Mattson, Jeremy G., Geurts, Aron M., Zogg, Mark, Weiler, Hartmut, Shi, Qizhen, Montgomery, Robert R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles: Hemostasis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971331/ https://www.ncbi.nlm.nih.gov/pubmed/31989086 http://dx.doi.org/10.1002/rth2.12280

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