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Δ-Tetrahydrocannabinol Increases Dopamine D1-D2 Receptor Heteromer and Elicits Phenotypic Reprogramming in Adult Primate Striatal Neurons

Long-term cannabis users manifest deficits in dopaminergic functions, reflecting Δ(9)-tetrahydrocannabinol (THC)-induced neuroadaptive dysfunctional dopamine signaling, similar to those observed upon dopamine D1-D2 heteromer activation. The molecular mechanisms remain largely unknown. We show evolut...

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Detalles Bibliográficos
Autores principales:	Hasbi, Ahmed, Madras, Bertha K., Bergman, Jack, Kohut, Stephen, Lin, Zhicheng, Withey, Sarah L., George, Susan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971351/ https://www.ncbi.nlm.nih.gov/pubmed/31972514 http://dx.doi.org/10.1016/j.isci.2019.100794

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