Islet Macrophages Shift to a Reparative State following Pancreatic Beta-Cell Death and Are a Major Source of Islet Insulin-like Growth Factor-1

Macrophages play a dynamic role in tissue repair following injury. Here we found that following streptozotocin (STZ)-induced beta-cell death, mouse islet macrophages had increased Igf1 expression, decreased proinflammatory cytokine expression, and transcriptome changes consistent with macrophages un...

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Detalles Bibliográficos
Autores principales: Nackiewicz, Dominika, Dan, Meixia, Speck, Madeleine, Chow, Samuel Z., Chen, Yi-Chun, Pospisilik, J. Andrew, Verchere, C. Bruce, Ehses, Jan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971395/
https://www.ncbi.nlm.nih.gov/pubmed/31962237
http://dx.doi.org/10.1016/j.isci.2019.100775

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