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Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids
In recent years, short-chain fatty acids (SCFAs) have been reported to play an important role in maintaining human health. Fecal SCFA concentrations correlate well with colonic SCFA status and gut microbiota composition. However, the associations with the gut microbiota functional pathway, dietary i...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMFH Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971417/ https://www.ncbi.nlm.nih.gov/pubmed/32010539 http://dx.doi.org/10.12938/bmfh.19-010 |
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author | YAMAMURA, Ryodai NAKAMURA, Koshi KITADA, Naoya AIZAWA, Tomoyasu SHIMIZU, Yu NAKAMURA, Kiminori AYABE, Tokiyoshi KIMURA, Takashi TAMAKOSHI, Akiko |
author_facet | YAMAMURA, Ryodai NAKAMURA, Koshi KITADA, Naoya AIZAWA, Tomoyasu SHIMIZU, Yu NAKAMURA, Kiminori AYABE, Tokiyoshi KIMURA, Takashi TAMAKOSHI, Akiko |
author_sort | YAMAMURA, Ryodai |
collection | PubMed |
description | In recent years, short-chain fatty acids (SCFAs) have been reported to play an important role in maintaining human health. Fecal SCFA concentrations correlate well with colonic SCFA status and gut microbiota composition. However, the associations with the gut microbiota functional pathway, dietary intake, blood SCFAs, and fecal SCFAs remain uncertain. To clarify these relationships, we collected fecal samples, blood samples, and dietary habit data from 12 healthy adults aged 22–51 years. The relative abundance of several SCFA-producing bacteria, gut microbiota diversity, and functional pathways related to SCFA biosynthesis were positively associated with fecal SCFAs even after adjusting for age and sex. Furthermore, fecal acetate was likely to be positively associated with serum acetate. By contrast, dietary intake was not associated with fecal SCFAs. Overall, the present study highlights the potential usefulness of fecal SCFAs as an indicator of the gut microbiota ecosystem and dynamics of SCFAs in the human body. |
format | Online Article Text |
id | pubmed-6971417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMFH Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-69714172020-01-31 Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids YAMAMURA, Ryodai NAKAMURA, Koshi KITADA, Naoya AIZAWA, Tomoyasu SHIMIZU, Yu NAKAMURA, Kiminori AYABE, Tokiyoshi KIMURA, Takashi TAMAKOSHI, Akiko Biosci Microbiota Food Health Full Paper In recent years, short-chain fatty acids (SCFAs) have been reported to play an important role in maintaining human health. Fecal SCFA concentrations correlate well with colonic SCFA status and gut microbiota composition. However, the associations with the gut microbiota functional pathway, dietary intake, blood SCFAs, and fecal SCFAs remain uncertain. To clarify these relationships, we collected fecal samples, blood samples, and dietary habit data from 12 healthy adults aged 22–51 years. The relative abundance of several SCFA-producing bacteria, gut microbiota diversity, and functional pathways related to SCFA biosynthesis were positively associated with fecal SCFAs even after adjusting for age and sex. Furthermore, fecal acetate was likely to be positively associated with serum acetate. By contrast, dietary intake was not associated with fecal SCFAs. Overall, the present study highlights the potential usefulness of fecal SCFAs as an indicator of the gut microbiota ecosystem and dynamics of SCFAs in the human body. BMFH Press 2019-10-05 2020 /pmc/articles/PMC6971417/ /pubmed/32010539 http://dx.doi.org/10.12938/bmfh.19-010 Text en ©2020 BMFH Press This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Full Paper YAMAMURA, Ryodai NAKAMURA, Koshi KITADA, Naoya AIZAWA, Tomoyasu SHIMIZU, Yu NAKAMURA, Kiminori AYABE, Tokiyoshi KIMURA, Takashi TAMAKOSHI, Akiko Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids |
title | Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids |
title_full | Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids |
title_fullStr | Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids |
title_full_unstemmed | Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids |
title_short | Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids |
title_sort | associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids |
topic | Full Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971417/ https://www.ncbi.nlm.nih.gov/pubmed/32010539 http://dx.doi.org/10.12938/bmfh.19-010 |
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