A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation

A dose-escalation study was conducted to find the effective dose of Lactococcus lactis subsp. cremoris FC for improving defecation in healthy subjects. Twenty-seven subjects were recruited and consecutively ingested a placebo and two dose levels of L. cremoris FC (dose level 1, 1 × 10(7) cfu; dose l...

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Detalles Bibliográficos
Autores principales: GOTOH, Yayoi, NANBA, Fumio, SHIOYA, Nobuhiko, SUGIMURA, Haruhi, SUZUKI, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMFH Press 2019
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971418/
https://www.ncbi.nlm.nih.gov/pubmed/32010540
http://dx.doi.org/10.12938/bmfh.19-009
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author GOTOH, Yayoi
NANBA, Fumio
SHIOYA, Nobuhiko
SUGIMURA, Haruhi
SUZUKI, Toshio
author_facet GOTOH, Yayoi
NANBA, Fumio
SHIOYA, Nobuhiko
SUGIMURA, Haruhi
SUZUKI, Toshio
author_sort GOTOH, Yayoi
collection PubMed
description A dose-escalation study was conducted to find the effective dose of Lactococcus lactis subsp. cremoris FC for improving defecation in healthy subjects. Twenty-seven subjects were recruited and consecutively ingested a placebo and two dose levels of L. cremoris FC (dose level 1, 1 × 10(7) cfu; dose level 2, 2 × 10(7) cfu) capsules daily for two weeks. Frequency of defecation (times/week) was significantly increased by dose level 2, and stool volume (units/week) was significantly increased by dose level 1. This dose-escalation study elucidated that intake of at least 1 × 10(7) cfu L. cremoris FC improves defecation.
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spelling pubmed-69714182020-01-31 A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation GOTOH, Yayoi NANBA, Fumio SHIOYA, Nobuhiko SUGIMURA, Haruhi SUZUKI, Toshio Biosci Microbiota Food Health Note A dose-escalation study was conducted to find the effective dose of Lactococcus lactis subsp. cremoris FC for improving defecation in healthy subjects. Twenty-seven subjects were recruited and consecutively ingested a placebo and two dose levels of L. cremoris FC (dose level 1, 1 × 10(7) cfu; dose level 2, 2 × 10(7) cfu) capsules daily for two weeks. Frequency of defecation (times/week) was significantly increased by dose level 2, and stool volume (units/week) was significantly increased by dose level 1. This dose-escalation study elucidated that intake of at least 1 × 10(7) cfu L. cremoris FC improves defecation. BMFH Press 2019-09-10 2020 /pmc/articles/PMC6971418/ /pubmed/32010540 http://dx.doi.org/10.12938/bmfh.19-009 Text en ©2020 BMFH Press This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Note
GOTOH, Yayoi
NANBA, Fumio
SHIOYA, Nobuhiko
SUGIMURA, Haruhi
SUZUKI, Toshio
A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation
title A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation
title_full A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation
title_fullStr A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation
title_full_unstemmed A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation
title_short A dose-finding study for a supplement containing Lactococcus lactis subsp. cremoris FC in healthy adults with mild constipation
title_sort dose-finding study for a supplement containing lactococcus lactis subsp. cremoris fc in healthy adults with mild constipation
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971418/
https://www.ncbi.nlm.nih.gov/pubmed/32010540
http://dx.doi.org/10.12938/bmfh.19-009
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