Towards mapping the 3D genome through high speed single-molecule tracking of functional transcription factors in single living cells

How genomic DNA is organized in the nucleus is a long-standing question. We describe a single-molecule bioimaging method utilizing super-localization precision coupled to fully quantitative image analysis tools, towards determining snapshots of parts of the 3D genome architecture of model eukaryote...

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Detalles Bibliográficos
Autores principales: Wollman, Adam J.M., Hedlund, Erik G., Shashkova, Sviatlana, Leake, Mark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971689/
https://www.ncbi.nlm.nih.gov/pubmed/31252059
http://dx.doi.org/10.1016/j.ymeth.2019.06.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971689/
https://www.ncbi.nlm.nih.gov/pubmed/31252059
http://dx.doi.org/10.1016/j.ymeth.2019.06.021

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