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AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY
The relationship between aging and changes in heart rate variability (HRV) could depend on the metabolic profile of obese people, i.e. metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO). We aimed to determine the age at which obesity related autonomic dysfunction becomes signi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971797/ https://www.ncbi.nlm.nih.gov/pubmed/31969754 http://dx.doi.org/10.20471/acc.2019.58.03.05 |
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author | Rastović, Marina Srdić-Galić, Biljana Barak, Otto Stokić, Edita Polovina, Snežana |
author_facet | Rastović, Marina Srdić-Galić, Biljana Barak, Otto Stokić, Edita Polovina, Snežana |
author_sort | Rastović, Marina |
collection | PubMed |
description | The relationship between aging and changes in heart rate variability (HRV) could depend on the metabolic profile of obese people, i.e. metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO). We aimed to determine the age at which obesity related autonomic dysfunction becomes significant and whether it decreases differently according to metabolic profile. We analyzed HRV in 99 adults using Wildman’s criteria for metabolic profile and 5-minute HRV for autonomic nervous system. In MHO, high frequency (HF) decreased in the 4(th) decade of life. In MUO, standard deviation of R-R intervals (SDNN), root mean square of successive differences of all R-R intervals (RMSSD), number of adjacent intervals differing by more than 50 ms expressed as percentage of all intervals in the collecting period (pNN50), HF, low frequency (LF), LF/HF (LF divided by HF) and total power (TP) decreased in the 4(th) decade of life (partial shared variance 28%-36%). In conclusion, an age dependent decrease of HRV occurs in MUO between the third and fifth decade of life. In MHO, HF significantly decreases around the age of 40 years. Cardiometabolic profile influences metabolic aging, altering the autonomic nervous system. |
format | Online Article Text |
id | pubmed-6971797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb |
record_format | MEDLINE/PubMed |
spelling | pubmed-69717972020-01-22 AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY Rastović, Marina Srdić-Galić, Biljana Barak, Otto Stokić, Edita Polovina, Snežana Acta Clin Croat Original Scientific Papers The relationship between aging and changes in heart rate variability (HRV) could depend on the metabolic profile of obese people, i.e. metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO). We aimed to determine the age at which obesity related autonomic dysfunction becomes significant and whether it decreases differently according to metabolic profile. We analyzed HRV in 99 adults using Wildman’s criteria for metabolic profile and 5-minute HRV for autonomic nervous system. In MHO, high frequency (HF) decreased in the 4(th) decade of life. In MUO, standard deviation of R-R intervals (SDNN), root mean square of successive differences of all R-R intervals (RMSSD), number of adjacent intervals differing by more than 50 ms expressed as percentage of all intervals in the collecting period (pNN50), HF, low frequency (LF), LF/HF (LF divided by HF) and total power (TP) decreased in the 4(th) decade of life (partial shared variance 28%-36%). In conclusion, an age dependent decrease of HRV occurs in MUO between the third and fifth decade of life. In MHO, HF significantly decreases around the age of 40 years. Cardiometabolic profile influences metabolic aging, altering the autonomic nervous system. Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb 2019-09 /pmc/articles/PMC6971797/ /pubmed/31969754 http://dx.doi.org/10.20471/acc.2019.58.03.05 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND) 4.0 License. |
spellingShingle | Original Scientific Papers Rastović, Marina Srdić-Galić, Biljana Barak, Otto Stokić, Edita Polovina, Snežana AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY |
title | AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY |
title_full | AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY |
title_fullStr | AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY |
title_full_unstemmed | AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY |
title_short | AGING, HEART RATE VARIABILITY AND METABOLIC IMPACT OF OBESITY |
title_sort | aging, heart rate variability and metabolic impact of obesity |
topic | Original Scientific Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971797/ https://www.ncbi.nlm.nih.gov/pubmed/31969754 http://dx.doi.org/10.20471/acc.2019.58.03.05 |
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