The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile

Background: The Avon Longitudinal Study of Parents and Children-Generation 2 (ALSPAC-G2) was set up to provide a unique multi-generational cohort. It builds on the existing ALSPAC resource, which recruited 14,541 pregnancies to women resident in the South West of England who were expected to deliver...

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Detalles Bibliográficos
Autores principales: Lawlor, Deborah A., Lewcock, Melanie, Rena-Jones, Louise, Rollings, Claire, Yip, Vikki, Smith, Daniel, Pearson, Rebecca M., Johnson, Laura, Millard, Louise A. C., Patel, Nashita, Skinner, Andy, Tilling, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971848/
https://www.ncbi.nlm.nih.gov/pubmed/31984238
http://dx.doi.org/10.12688/wellcomeopenres.15087.2
Descripción
Sumario:Background: The Avon Longitudinal Study of Parents and Children-Generation 2 (ALSPAC-G2) was set up to provide a unique multi-generational cohort. It builds on the existing ALSPAC resource, which recruited 14,541 pregnancies to women resident in the South West of England who were expected to deliver between 01/04/1991 and 31/12/1992. Those women and their partners (Generation 0; ALSPAC-G0) and their offspring (ALSPAC-G1) have been followed for the last 27 years. This profile describes recruitment and data collection on the next generation (ALSPAC-G2)—the grandchildren of ALSPAC-G0 and children of ALSPAC-G1. Recruitment: Recruitment began on the 6 (th) of June 2012 and we present details of recruitment and participants up to 30 (th) June 2018 (~6 years). We knew at the start of recruitment that some ALSPAC-G1 participants had already become parents and ALSPAC-G2 is an open cohort; we recruit at any age. We hope to continue recruiting until all ALSPAC-G1 participants have completed their families. Up to 30 (th) June 2018 we recruited 810 ALSPAC-G2 participants from 548 families. Of these 810, 389 (48%) were recruited during their mother’s pregnancy, 287 (35%) before age 3 years, 104 (13%) between 3-6 years and 30 (4%) after 6 years. Over 70% of those invited to early pregnancy, late pregnancy, second week of life, 6-, 12- and 24-month assessments (whether for their recruitment, or a follow-up, visit) have attended, with attendance being over 60% for subsequent visits up to 7 years (too few are eligible for the 9- and 11-year assessments to analyse). Data collection: We collect a wide-range of socioeconomic, lifestyle, clinical, anthropometric and biological data on all family members repeatedly. Biological samples include blood (including cord-blood), urine, meconium and faeces, and placental tissue. In subgroups detailed data collection, such as continuous glucose monitoring and videos of parent-child interactions, are being collected.

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