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The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile
Background: The Avon Longitudinal Study of Parents and Children-Generation 2 (ALSPAC-G2) was set up to provide a unique multi-generational cohort. It builds on the existing ALSPAC resource, which recruited 14,541 pregnancies to women resident in the South West of England who were expected to deliver...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000 Research Limited
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971848/ https://www.ncbi.nlm.nih.gov/pubmed/31984238 http://dx.doi.org/10.12688/wellcomeopenres.15087.2 |
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author | Lawlor, Deborah A. Lewcock, Melanie Rena-Jones, Louise Rollings, Claire Yip, Vikki Smith, Daniel Pearson, Rebecca M. Johnson, Laura Millard, Louise A. C. Patel, Nashita Skinner, Andy Tilling, Kate |
author_facet | Lawlor, Deborah A. Lewcock, Melanie Rena-Jones, Louise Rollings, Claire Yip, Vikki Smith, Daniel Pearson, Rebecca M. Johnson, Laura Millard, Louise A. C. Patel, Nashita Skinner, Andy Tilling, Kate |
author_sort | Lawlor, Deborah A. |
collection | PubMed |
description | Background: The Avon Longitudinal Study of Parents and Children-Generation 2 (ALSPAC-G2) was set up to provide a unique multi-generational cohort. It builds on the existing ALSPAC resource, which recruited 14,541 pregnancies to women resident in the South West of England who were expected to deliver between 01/04/1991 and 31/12/1992. Those women and their partners (Generation 0; ALSPAC-G0) and their offspring (ALSPAC-G1) have been followed for the last 27 years. This profile describes recruitment and data collection on the next generation (ALSPAC-G2)—the grandchildren of ALSPAC-G0 and children of ALSPAC-G1. Recruitment: Recruitment began on the 6 (th) of June 2012 and we present details of recruitment and participants up to 30 (th) June 2018 (~6 years). We knew at the start of recruitment that some ALSPAC-G1 participants had already become parents and ALSPAC-G2 is an open cohort; we recruit at any age. We hope to continue recruiting until all ALSPAC-G1 participants have completed their families. Up to 30 (th) June 2018 we recruited 810 ALSPAC-G2 participants from 548 families. Of these 810, 389 (48%) were recruited during their mother’s pregnancy, 287 (35%) before age 3 years, 104 (13%) between 3-6 years and 30 (4%) after 6 years. Over 70% of those invited to early pregnancy, late pregnancy, second week of life, 6-, 12- and 24-month assessments (whether for their recruitment, or a follow-up, visit) have attended, with attendance being over 60% for subsequent visits up to 7 years (too few are eligible for the 9- and 11-year assessments to analyse). Data collection: We collect a wide-range of socioeconomic, lifestyle, clinical, anthropometric and biological data on all family members repeatedly. Biological samples include blood (including cord-blood), urine, meconium and faeces, and placental tissue. In subgroups detailed data collection, such as continuous glucose monitoring and videos of parent-child interactions, are being collected. |
format | Online Article Text |
id | pubmed-6971848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | F1000 Research Limited |
record_format | MEDLINE/PubMed |
spelling | pubmed-69718482020-01-24 The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile Lawlor, Deborah A. Lewcock, Melanie Rena-Jones, Louise Rollings, Claire Yip, Vikki Smith, Daniel Pearson, Rebecca M. Johnson, Laura Millard, Louise A. C. Patel, Nashita Skinner, Andy Tilling, Kate Wellcome Open Res Research Article Background: The Avon Longitudinal Study of Parents and Children-Generation 2 (ALSPAC-G2) was set up to provide a unique multi-generational cohort. It builds on the existing ALSPAC resource, which recruited 14,541 pregnancies to women resident in the South West of England who were expected to deliver between 01/04/1991 and 31/12/1992. Those women and their partners (Generation 0; ALSPAC-G0) and their offspring (ALSPAC-G1) have been followed for the last 27 years. This profile describes recruitment and data collection on the next generation (ALSPAC-G2)—the grandchildren of ALSPAC-G0 and children of ALSPAC-G1. Recruitment: Recruitment began on the 6 (th) of June 2012 and we present details of recruitment and participants up to 30 (th) June 2018 (~6 years). We knew at the start of recruitment that some ALSPAC-G1 participants had already become parents and ALSPAC-G2 is an open cohort; we recruit at any age. We hope to continue recruiting until all ALSPAC-G1 participants have completed their families. Up to 30 (th) June 2018 we recruited 810 ALSPAC-G2 participants from 548 families. Of these 810, 389 (48%) were recruited during their mother’s pregnancy, 287 (35%) before age 3 years, 104 (13%) between 3-6 years and 30 (4%) after 6 years. Over 70% of those invited to early pregnancy, late pregnancy, second week of life, 6-, 12- and 24-month assessments (whether for their recruitment, or a follow-up, visit) have attended, with attendance being over 60% for subsequent visits up to 7 years (too few are eligible for the 9- and 11-year assessments to analyse). Data collection: We collect a wide-range of socioeconomic, lifestyle, clinical, anthropometric and biological data on all family members repeatedly. Biological samples include blood (including cord-blood), urine, meconium and faeces, and placental tissue. In subgroups detailed data collection, such as continuous glucose monitoring and videos of parent-child interactions, are being collected. F1000 Research Limited 2019-12-16 /pmc/articles/PMC6971848/ /pubmed/31984238 http://dx.doi.org/10.12688/wellcomeopenres.15087.2 Text en Copyright: © 2019 Lawlor DA et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Lawlor, Deborah A. Lewcock, Melanie Rena-Jones, Louise Rollings, Claire Yip, Vikki Smith, Daniel Pearson, Rebecca M. Johnson, Laura Millard, Louise A. C. Patel, Nashita Skinner, Andy Tilling, Kate The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile |
title | The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile |
title_full | The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile |
title_fullStr | The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile |
title_full_unstemmed | The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile |
title_short | The second generation of The Avon Longitudinal Study of Parents and Children (ALSPAC-G2): a cohort profile |
title_sort | second generation of the avon longitudinal study of parents and children (alspac-g2): a cohort profile |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971848/ https://www.ncbi.nlm.nih.gov/pubmed/31984238 http://dx.doi.org/10.12688/wellcomeopenres.15087.2 |
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