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Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response

BACKGROUND: Hypoxic tumors are refractory to DNA damage drugs. However, the underlying mechanism has yet to be elucidated. We aimed to identify lncRNAs that upregulated under hypoxia and their effects on colorectal cancer (CRC). METHODS: CRC cells were treated with 1% O(2) to identify lncRNAs that u...

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Detalles Bibliográficos
Autores principales: Huan, Lin, Guo, Tianan, Wu, Yangjun, Xu, Linguo, Huang, Shenglin, Xu, Ye, Liang, Linhui, He, Xianghuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971890/
https://www.ncbi.nlm.nih.gov/pubmed/31964396
http://dx.doi.org/10.1186/s12943-019-1122-z