ALS-linked TDP-43(M337V) knock-in mice exhibit splicing deregulation without neurodegeneration

Abnormal accumulation of TAR DNA-binding protein 43 (TDP-43), a DNA/RNA binding protein, is a pathological signature of amyotrophic lateral sclerosis (ALS). Missense mutations in the TARDBP gene are also found in inherited and sporadic ALS, indicating that dysfunction in TDP-43 is causative for ALS....

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Detalles Bibliográficos
Autores principales: Watanabe, Seiji, Oiwa, Kotaro, Murata, Yuri, Komine, Okiru, Sobue, Akira, Endo, Fumito, Takahashi, Eiki, Yamanaka, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Micro Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971932/
https://www.ncbi.nlm.nih.gov/pubmed/31959210
http://dx.doi.org/10.1186/s13041-020-0550-4

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