An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies

BACKGROUND: Aging is a complex irreversible process that is not only related to an individual’s genetic make-up but also to lifestyle choices and environmental exposures. Like every other structure in human body, the Neuromuscular Junction (NMJ) is not averse to aging. OBJECTIVES: The prime objectiv...

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Autores principales: Khosa, Shaweta, Trikamji, Bhavesh, Khosa, Gurveer S., Khanli, Hadi M., Mishra, Shri K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971950/
https://www.ncbi.nlm.nih.gov/pubmed/31161982
http://dx.doi.org/10.2174/1874609812666190603165746
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author Khosa, Shaweta
Trikamji, Bhavesh
Khosa, Gurveer S.
Khanli, Hadi M.
Mishra, Shri K.
author_facet Khosa, Shaweta
Trikamji, Bhavesh
Khosa, Gurveer S.
Khanli, Hadi M.
Mishra, Shri K.
author_sort Khosa, Shaweta
collection PubMed
description BACKGROUND: Aging is a complex irreversible process that is not only related to an individual’s genetic make-up but also to lifestyle choices and environmental exposures. Like every other structure in human body, the Neuromuscular Junction (NMJ) is not averse to aging. OBJECTIVES: The prime objective is to analyse the microscopic and macroscopic changes at the NMJs with aging. METHODS: For the purpose of review we evaluated data from resources like Pubmed, Ovid, UCLA libraries and USC libraries. RESULTS: We review various morphological, physiological, immunological, and biochemical changes in NMJs with aging and their management. CONCLUSION: The alterations in NMJs secondary to aging are inevitable. It is vital that neurologists clearly understand the pathophysiology of NMJ aging and differentiate between physiological and pathological effects of aging. With the current knowledge of science, the changes in NMJ aging can be better prevented rather than cured.
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spelling pubmed-69719502020-02-06 An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies Khosa, Shaweta Trikamji, Bhavesh Khosa, Gurveer S. Khanli, Hadi M. Mishra, Shri K. Curr Aging Sci Article BACKGROUND: Aging is a complex irreversible process that is not only related to an individual’s genetic make-up but also to lifestyle choices and environmental exposures. Like every other structure in human body, the Neuromuscular Junction (NMJ) is not averse to aging. OBJECTIVES: The prime objective is to analyse the microscopic and macroscopic changes at the NMJs with aging. METHODS: For the purpose of review we evaluated data from resources like Pubmed, Ovid, UCLA libraries and USC libraries. RESULTS: We review various morphological, physiological, immunological, and biochemical changes in NMJs with aging and their management. CONCLUSION: The alterations in NMJs secondary to aging are inevitable. It is vital that neurologists clearly understand the pathophysiology of NMJ aging and differentiate between physiological and pathological effects of aging. With the current knowledge of science, the changes in NMJ aging can be better prevented rather than cured. Bentham Science Publishers 2019-05 2019-05 /pmc/articles/PMC6971950/ /pubmed/31161982 http://dx.doi.org/10.2174/1874609812666190603165746 Text en © 2019 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Khosa, Shaweta
Trikamji, Bhavesh
Khosa, Gurveer S.
Khanli, Hadi M.
Mishra, Shri K.
An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies
title An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies
title_full An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies
title_fullStr An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies
title_full_unstemmed An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies
title_short An Overview of Neuromuscular Junction Aging Findings in Human and Animal Studies
title_sort overview of neuromuscular junction aging findings in human and animal studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971950/
https://www.ncbi.nlm.nih.gov/pubmed/31161982
http://dx.doi.org/10.2174/1874609812666190603165746
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