WEE1 inhibition synergizes with CHOP chemotherapy and radiation therapy through induction of premature mitotic entry and DNA damage in diffuse large B-cell lymphoma

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, characterized by high levels of genomic instability and the activation of DNA damage repair pathways. We previously found high expression of the cell cycle regulator WEE1 in DLBCL cell lines. Here, we investigated the comb...

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Detalles Bibliográficos
Autores principales: de Jong, Mathilde R. W., Langendonk, Myra, Reitsma, Bart, Herbers, Pien, Lodewijk, Monique, Nijland, Marcel, van den Berg, Anke, Ammatuna, Emanuele, Visser, Lydia, van Meerten, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971956/
https://www.ncbi.nlm.nih.gov/pubmed/32010435
http://dx.doi.org/10.1177/2040620719898373

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