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Application of the 2017 McDonald criteria in a Chinese population with clinically isolated syndrome

BACKGROUND: Diagnostic criteria for multiple sclerosis have evolved over time, with the most recent being the 2017 McDonald criteria. Evidence is lacking regarding the validity of the 2017 McDonald criteria among the Asian population. Therefore, this study aims to evaluate the diagnostic performance...

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Autores principales: Zheng*, Yang, Shen*, Chun-Hong, Wang, Sa, Yang, Fan, Cai, Meng-Ting, Fang, Wei, Zhang, Yin-Xi, Ding, Mei-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971959/
https://www.ncbi.nlm.nih.gov/pubmed/32010225
http://dx.doi.org/10.1177/1756286419898083
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author Zheng*, Yang
Shen*, Chun-Hong
Wang, Sa
Yang, Fan
Cai, Meng-Ting
Fang, Wei
Zhang, Yin-Xi
Ding, Mei-Ping
author_facet Zheng*, Yang
Shen*, Chun-Hong
Wang, Sa
Yang, Fan
Cai, Meng-Ting
Fang, Wei
Zhang, Yin-Xi
Ding, Mei-Ping
author_sort Zheng*, Yang
collection PubMed
description BACKGROUND: Diagnostic criteria for multiple sclerosis have evolved over time, with the most recent being the 2017 McDonald criteria. Evidence is lacking regarding the validity of the 2017 McDonald criteria among the Asian population. Therefore, this study aims to evaluate the diagnostic performance of the 2017 McDonald criteria in Chinese patients with clinically isolated syndrome (CIS). METHODS: A total of 93 patients with initial findings suggestive of CIS in a tertiary hospital in China from 2012 to 2017 were included in this retrospective study. Baseline and follow-up data were reviewed. Diagnostic performance (sensitivity, specificity, accuracy), was assessed and survival analysis was performed for the 2017 and 2010 McDonald criteria respectively. RESULTS: Among the 93 Chinese patients with CIS, 57 were female (61.3%) and the median (interquartile range) age of onset was 37 (31.3–41.8) years. The 2017 McDonald criteria displayed a higher sensitivity (75.0% versus 14.6%, p < 0.0001), lower specificity (47.1% versus 100.0%, p < 0.05) but an overall higher accuracy (67.7% versus 36.9%, p < 0.0001) when compared with the 2010 iteration. The novel criteria allow for a better detection of MS at baseline (40.8% versus 9.9%, p < 0.0001). CONCLUSION: The 2017 McDonald criteria had a higher sensitivity but lower specificity than the 2010 iteration. Overall it facilitated an earlier and more accurate diagnosis of multiple sclerosis in Chinese patients with CIS.
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spelling pubmed-69719592020-01-31 Application of the 2017 McDonald criteria in a Chinese population with clinically isolated syndrome Zheng*, Yang Shen*, Chun-Hong Wang, Sa Yang, Fan Cai, Meng-Ting Fang, Wei Zhang, Yin-Xi Ding, Mei-Ping Ther Adv Neurol Disord Autoimmune Neurology BACKGROUND: Diagnostic criteria for multiple sclerosis have evolved over time, with the most recent being the 2017 McDonald criteria. Evidence is lacking regarding the validity of the 2017 McDonald criteria among the Asian population. Therefore, this study aims to evaluate the diagnostic performance of the 2017 McDonald criteria in Chinese patients with clinically isolated syndrome (CIS). METHODS: A total of 93 patients with initial findings suggestive of CIS in a tertiary hospital in China from 2012 to 2017 were included in this retrospective study. Baseline and follow-up data were reviewed. Diagnostic performance (sensitivity, specificity, accuracy), was assessed and survival analysis was performed for the 2017 and 2010 McDonald criteria respectively. RESULTS: Among the 93 Chinese patients with CIS, 57 were female (61.3%) and the median (interquartile range) age of onset was 37 (31.3–41.8) years. The 2017 McDonald criteria displayed a higher sensitivity (75.0% versus 14.6%, p < 0.0001), lower specificity (47.1% versus 100.0%, p < 0.05) but an overall higher accuracy (67.7% versus 36.9%, p < 0.0001) when compared with the 2010 iteration. The novel criteria allow for a better detection of MS at baseline (40.8% versus 9.9%, p < 0.0001). CONCLUSION: The 2017 McDonald criteria had a higher sensitivity but lower specificity than the 2010 iteration. Overall it facilitated an earlier and more accurate diagnosis of multiple sclerosis in Chinese patients with CIS. SAGE Publications 2020-01-20 /pmc/articles/PMC6971959/ /pubmed/32010225 http://dx.doi.org/10.1177/1756286419898083 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Autoimmune Neurology
Zheng*, Yang
Shen*, Chun-Hong
Wang, Sa
Yang, Fan
Cai, Meng-Ting
Fang, Wei
Zhang, Yin-Xi
Ding, Mei-Ping
Application of the 2017 McDonald criteria in a Chinese population with clinically isolated syndrome
title Application of the 2017 McDonald criteria in a Chinese population with clinically isolated syndrome
title_full Application of the 2017 McDonald criteria in a Chinese population with clinically isolated syndrome
title_fullStr Application of the 2017 McDonald criteria in a Chinese population with clinically isolated syndrome
title_full_unstemmed Application of the 2017 McDonald criteria in a Chinese population with clinically isolated syndrome
title_short Application of the 2017 McDonald criteria in a Chinese population with clinically isolated syndrome
title_sort application of the 2017 mcdonald criteria in a chinese population with clinically isolated syndrome
topic Autoimmune Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971959/
https://www.ncbi.nlm.nih.gov/pubmed/32010225
http://dx.doi.org/10.1177/1756286419898083
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