Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice

Prekallikrein (PKK, also known as Fletcher factor and encoded by the gene KLKB1 in humans) is a component of the contact system. Activation of the contact system has been implicated in lethality in fulminant sepsis models. Pneumonia is the most frequent cause of sepsis. We sought to determine the ro...

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Detalles Bibliográficos
Autores principales: Ding, Chao, Scicluna, Brendon P, Stroo, Ingrid, Yang, Jack, Roelofs, Joris JTH, de Boer, Onno J, de Vos, Alex F, Nürnberg, Peter, Revenko, Alexey S, Crosby, Jeff, van't Veer, Cornelis, van der Poll, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972537/
https://www.ncbi.nlm.nih.gov/pubmed/31595971
http://dx.doi.org/10.1002/path.5354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972537/
https://www.ncbi.nlm.nih.gov/pubmed/31595971
http://dx.doi.org/10.1002/path.5354

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