Mild, Selective Ru‐Catalyzed Deuteration Using D(2)O as a Deuterium Source

A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl(2)(PPh(3))(3)] and D(2)O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration...

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Detalles Bibliográficos
Autores principales: Eisele, Pascal, Ullwer, Franziska, Scholz, Sven, Plietker, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972544/
https://www.ncbi.nlm.nih.gov/pubmed/31680359
http://dx.doi.org/10.1002/chem.201904927
Descripción
Sumario:A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl(2)(PPh(3))(3)] and D(2)O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration process are observed. Mechanistic investigation indicates the presence of different, defined Ru‐complexes under the given specific conditions.

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