Mild, Selective Ru‐Catalyzed Deuteration Using D(2)O as a Deuterium Source

A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl(2)(PPh(3))(3)] and D(2)O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration...

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Detalles Bibliográficos
Autores principales: Eisele, Pascal, Ullwer, Franziska, Scholz, Sven, Plietker, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972544/
https://www.ncbi.nlm.nih.gov/pubmed/31680359
http://dx.doi.org/10.1002/chem.201904927
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author Eisele, Pascal
Ullwer, Franziska
Scholz, Sven
Plietker, Bernd
author_facet Eisele, Pascal
Ullwer, Franziska
Scholz, Sven
Plietker, Bernd
author_sort Eisele, Pascal
collection PubMed
description A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl(2)(PPh(3))(3)] and D(2)O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration process are observed. Mechanistic investigation indicates the presence of different, defined Ru‐complexes under the given specific conditions.
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spelling pubmed-69725442020-01-27 Mild, Selective Ru‐Catalyzed Deuteration Using D(2)O as a Deuterium Source Eisele, Pascal Ullwer, Franziska Scholz, Sven Plietker, Bernd Chemistry Communications A method for the selective deuteration of polyfunctional organic molecules using catalytic amounts of [RuCl(2)(PPh(3))(3)] and D(2)O as a deuterium source is presented. Through variation of additives like CuI, KOH, and various amounts of zinc powder, orthogonal chemoselectivities in the deuteration process are observed. Mechanistic investigation indicates the presence of different, defined Ru‐complexes under the given specific conditions. John Wiley and Sons Inc. 2019-11-28 2019-12-20 /pmc/articles/PMC6972544/ /pubmed/31680359 http://dx.doi.org/10.1002/chem.201904927 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Eisele, Pascal
Ullwer, Franziska
Scholz, Sven
Plietker, Bernd
Mild, Selective Ru‐Catalyzed Deuteration Using D(2)O as a Deuterium Source
title Mild, Selective Ru‐Catalyzed Deuteration Using D(2)O as a Deuterium Source
title_full Mild, Selective Ru‐Catalyzed Deuteration Using D(2)O as a Deuterium Source
title_fullStr Mild, Selective Ru‐Catalyzed Deuteration Using D(2)O as a Deuterium Source
title_full_unstemmed Mild, Selective Ru‐Catalyzed Deuteration Using D(2)O as a Deuterium Source
title_short Mild, Selective Ru‐Catalyzed Deuteration Using D(2)O as a Deuterium Source
title_sort mild, selective ru‐catalyzed deuteration using d(2)o as a deuterium source
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972544/
https://www.ncbi.nlm.nih.gov/pubmed/31680359
http://dx.doi.org/10.1002/chem.201904927
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