Lysosomal size matters

Lysosomes are key cellular catabolic centers that also perform fundamental metabolic, signaling and quality control functions. Lysosomes are not static and they respond dynamically to intra‐ and extracellular stimuli triggering changes in organelle numbers, size and position. Such physical changes h...

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Detalles Bibliográficos
Autores principales: de Araujo, Mariana E. G., Liebscher, Gudrun, Hess, Michael W., Huber, Lukas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons A/S 2019
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972631/
https://www.ncbi.nlm.nih.gov/pubmed/31808235
http://dx.doi.org/10.1111/tra.12714
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author de Araujo, Mariana E. G.
Liebscher, Gudrun
Hess, Michael W.
Huber, Lukas A.
author_facet de Araujo, Mariana E. G.
Liebscher, Gudrun
Hess, Michael W.
Huber, Lukas A.
author_sort de Araujo, Mariana E. G.
collection PubMed
description Lysosomes are key cellular catabolic centers that also perform fundamental metabolic, signaling and quality control functions. Lysosomes are not static and they respond dynamically to intra‐ and extracellular stimuli triggering changes in organelle numbers, size and position. Such physical changes have a strong impact on lysosomal activity ultimately influencing cellular homeostasis. In this review, we summarize the current knowledge on lysosomal size regulation, on its physiological role(s) and association to several disease conditions.
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spelling pubmed-69726312020-01-27 Lysosomal size matters de Araujo, Mariana E. G. Liebscher, Gudrun Hess, Michael W. Huber, Lukas A. Traffic Reviews Lysosomes are key cellular catabolic centers that also perform fundamental metabolic, signaling and quality control functions. Lysosomes are not static and they respond dynamically to intra‐ and extracellular stimuli triggering changes in organelle numbers, size and position. Such physical changes have a strong impact on lysosomal activity ultimately influencing cellular homeostasis. In this review, we summarize the current knowledge on lysosomal size regulation, on its physiological role(s) and association to several disease conditions. John Wiley & Sons A/S 2019-12-06 2020-01 /pmc/articles/PMC6972631/ /pubmed/31808235 http://dx.doi.org/10.1111/tra.12714 Text en © 2019 The Authors. Traffic published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
de Araujo, Mariana E. G.
Liebscher, Gudrun
Hess, Michael W.
Huber, Lukas A.
Lysosomal size matters
title Lysosomal size matters
title_full Lysosomal size matters
title_fullStr Lysosomal size matters
title_full_unstemmed Lysosomal size matters
title_short Lysosomal size matters
title_sort lysosomal size matters
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972631/
https://www.ncbi.nlm.nih.gov/pubmed/31808235
http://dx.doi.org/10.1111/tra.12714
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AT liebschergudrun lysosomalsizematters
AT hessmichaelw lysosomalsizematters
AT huberlukasa lysosomalsizematters

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