Cargando…

HBV X protein mutations affect HBV transcription and association of histone-modifying enzymes with covalently closed circular DNA

The hepatitis B X protein (HBx) plays a role in the epigenetic regulation of hepatitis B virus (HBV) replication. This study investigated the effects of HBx mutations on HBV transcription and the recruitment of HBx, histone acetyl-transferase P300 and histone deacetylase 1 (HDAC1) to circularized HB...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chong, Chun Kong, Cheng, Ching Yan Serene, Tsoi, Sin Yi Jasmine, Huang, Fung-Yu, Liu, Fen, Fung, James, Seto, Wai-Kay, Lai, Keane K.-Y., Lai, Ching-Lung, Yuen, Man-Fung, Wong, Danny Ka-Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972884/ https://www.ncbi.nlm.nih.gov/pubmed/31964944 http://dx.doi.org/10.1038/s41598-020-57637-z

Ejemplares similares

Rebound of HBV DNA after cessation of nucleos/tide analogues in chronic hepatitis B patients with undetectable covalently closed
por: Lai, Ching-Lung, et al.
Publicado: (2020)

Nucleic Acid Testing for the Detection of HBV DNA
por: Seto, Wai Kay, et al.
Publicado: (2011)

Targeted genomic profiling identifies frequent deleterious mutations in FAT4 and TP53 genes in HBV-associated hepatocellular carcinoma
por: Huang, Fung-Yu, et al.
Publicado: (2019)

Detection of HBV Covalently Closed Circular DNA
por: Li, Xiaoling, et al.
Publicado: (2017)

Differences in sequences between HBV-relaxed circular DNA and covalently closed circular DNA
por: Rybicka, Magda, et al.
Publicado: (2017)

Estradiol induces apoptosis via activation of miRNA-23a and p53: implication for gender difference in liver cancer development
por: Huang, Fung-Yu, et al.
Publicado: (2015)

Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients
por: Mak, Lung-Yi, et al.
Publicado: (2019)

Correspondence on Editorial regarding “HBV pgRNA and HBcrAg reductions at week 4 predict favourable HBsAg response upon long-term nucleos(t)ide analogue in CHB”
por: Mak, Lung-Yi, et al.
Publicado: (2023)

Evolutionary Changes of Hepatitis B Virus Pre-S Mutations Prior to Development of Hepatocellular Carcinoma
por: Zhang, An-Ye, et al.
Publicado: (2015)

Prognostic Factors for Transplant-Free Survival and Validation of Prognostic Models in Chinese Patients with Primary Biliary Cholangitis Receiving Ursodeoxycholic Acid
por: Cheung, Ka-Shing, et al.
Publicado: (2017)

Epidemiology and Natural History of Primary Biliary Cholangitis in the Chinese: A Territory-Based Study in Hong Kong between 2000 and 2015
por: Cheung, Ka-Shing, et al.
Publicado: (2017)

The use of transient elastography in the management of chronic hepatitis B
por: Fung, James, et al.
Publicado: (2011)

Prediction of hepatocellular carcinoma development by aminotransferase to platelet ratio index in primary biliary cholangitis
por: Cheung, Ka-Shing, et al.
Publicado: (2017)

Epidemiology and natural history of Wilson’s disease in the Chinese: A territory-based study in Hong Kong between 2000 and 2016
por: Cheung, Ka-Shing, et al.
Publicado: (2017)

Reduction of liver stiffness following resolution of acute flares of chronic hepatitis B
por: Fung, James, et al.
Publicado: (2010)

Defining Normal Liver Stiffness Range in a Normal Healthy Chinese Population without Liver Disease
por: Fung, James, et al.
Publicado: (2013)

HBsAg Loss as a Treatment Endpoint for Chronic HBV Infection: HBV Cure
por: Moini, Maryam, et al.
Publicado: (2022)

Role of serum M2BPGi levels on diagnosing significant liver fibrosis and cirrhosis in treated patients with chronic hepatitis B virus infection
por: Mak, Lung-Yi, et al.
Publicado: (2018)

Wisteria floribunda agglutinin-positive human Mac-2 binding protein predicts liver cancer development in chronic hepatitis B patients under antiviral treatment
por: Cheung, Ka-Shing, et al.
Publicado: (2017)

Sequence Variations of Full-Length Hepatitis B Virus Genomes in Chinese Patients with HBsAg-Negative Hepatitis B Infection
por: Huang, Fung-Yu, et al.
Publicado: (2014)

Serum hepatitis B surface antigen (HBsAg) kinetics in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B
por: Seto, Wai-Kay, et al.
Publicado: (2012)

Seven-Year Treatment Outcome of Entecavir in a Real-World Cohort: Effects on Clinical Parameters, HBsAg and HBcrAg Levels
por: Lam, Yuk-Fai, et al.
Publicado: (2017)

A new model mimicking persistent HBV e antigen-negative infection using covalently closed circular DNA in immunocompetent mice
por: Wang, Lei, et al.
Publicado: (2017)

LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1
por: Sun, Yang, et al.
Publicado: (2022)

Current Antiviral Therapy of Chronic Hepatitis B: Efficacy and Safety
por: Lam, Yuk-Fai, et al.
Publicado: (2011)

Epidemiology of Hepatocellular Carcinoma in the Asia-Pacific Region
por: Zhu, Ran Xu, et al.
Publicado: (2016)

Role of HLA-DP Polymorphisms on Chronicity and Disease Activity of Hepatitis B Infection in Southern Chinese
por: Wong, Danny Ka-Ho, et al.
Publicado: (2013)

Forkhead O Transcription Factor 4 Restricts HBV Covalently Closed Circular DNA Transcription and HBV Replication through Genetic Downregulation of Hepatocyte Nuclear Factor 4 Alpha and Epigenetic Suppression of Covalently Closed Circular DNA via Interacting with Promyelocytic Leukemia Protein
por: Li, Yuqi, et al.
Publicado: (2022)

A Large Population Histology Study Showing the Lack of Association between ALT Elevation and Significant Fibrosis in Chronic Hepatitis B
por: Seto, Wai-Kay, et al.
Publicado: (2012)

High Hepatitis B Surface Antigen Levels Predict Insignificant Fibrosis in Hepatitis B e Antigen Positive Chronic Hepatitis B
por: Seto, Wai-Kay, et al.
Publicado: (2012)

A New Model Using Routinely Available Clinical Parameters to Predict Significant Liver Fibrosis in Chronic Hepatitis B
por: Seto, Wai-Kay, et al.
Publicado: (2011)

The Role of Steatosis in HBsAg Seroclearance for Patients with Chronic Hepatitis B Infection: Fact or Fiction?
por: Fung, James, et al.
Publicado: (2012)

Evidence of serologic activity in chronic hepatitis B after surface antigen (HBsAg) seroclearance documented by conventional HBsAg assay
por: Seto, Wai-Kay, et al.
Publicado: (2012)

The Infection Efficiency and Replication Ability of Circularized HBV DNA Optimized the Linear HBV DNA in Vitro and in Vivo
por: Li, Xiaosong, et al.
Publicado: (2015)

First-line oral antiviral therapies showed similar efficacies in suppression of serum HBcrAg in chronic hepatitis B patients
por: Mak, Lung-Yi, et al.
Publicado: (2021)

Entecavir Reduced Serum Hepatitis B Core-Related Antigen in Chronic Hepatitis B Patients with Hepatocellular Carcinoma
por: Mak, Lung-Yi, et al.
Publicado: (2020)

Increasing antiviral treatment uptake improves survival in patients with HBV-related HCC
por: Hui, Vicki Wing-Ki, et al.
Publicado: (2020)

Sex‐specific analysis of microRNA profiles in HBV‐associated cirrhosis by small RNA‐sequencing
por: Chan, Kristy Kwan‐Shuen, et al.
Publicado: (2022)

Entecavir vs Tenofovir in Hepatocellular Carcinoma Prevention in Chronic Hepatitis B Infection: A Systematic Review and Meta-Analysis
por: Cheung, Ka Shing, et al.
Publicado: (2020)

Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma
por: Huang, Fung-Yu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_efuiduseqe43uvae4akqtfunkt