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Structural insight into small molecule action on Frizzleds

WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, stem cell regulation and tissue homeostasis. FZDs are linked to severe human pathology and are seen as a promising target for therapy. Despite intense efforts, no small molecule drugs with distinct efficacy have emerged. He...

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Detalles Bibliográficos
Autores principales:	Kozielewicz, Paweł, Turku, Ainoleena, Bowin, Carl-Fredrik, Petersen, Julian, Valnohova, Jana, Cañizal, Maria Consuelo Alonso, Ono, Yuki, Inoue, Asuka, Hoffmann, Carsten, Schulte, Gunnar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972889/ https://www.ncbi.nlm.nih.gov/pubmed/31964872 http://dx.doi.org/10.1038/s41467-019-14149-3

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