Novel inhibitor ZED3197 as potential drug candidate in anticoagulation targeting coagulation FXIIIa (F13a)

BACKGROUND: Factor XIII (FXIII) is the final enzyme of the coagulation cascade. While the other enzymatic coagulation factors are proteases, FXIII belongs to the transglutaminase family. FXIIIa covalently crosslinks the fibrin clot and represents a promising target for drug development to facilitate...

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Detalles Bibliográficos
Autores principales: Pasternack, Ralf, Büchold, Christian, Jähnig, Robert, Pelzer, Christiane, Sommer, Michael, Heil, Andreas, Florian, Peter, Nowak, Götz, Gerlach, Uwe, Hils, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
THROMBOSIS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973046/
https://www.ncbi.nlm.nih.gov/pubmed/31578814
http://dx.doi.org/10.1111/jth.14646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973046/
https://www.ncbi.nlm.nih.gov/pubmed/31578814
http://dx.doi.org/10.1111/jth.14646

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