DNA methylation analysis of multiple imprinted DMRs in Sotos syndrome reveals IGF2‐DMR0 as a DNA methylation‐dependent, P0 promoter‐specific enhancer

Haploinsufficiency of NSD1, which dimethylates histone H3 lysine 36 (H3K36), causes Sotos syndrome (SoS), an overgrowth syndrome. DNMT3A and DNMT3B recognizes H3K36 trimethylation (H3K36me3) through PWWP domain to exert de novo DNA methyltransferase activity and establish imprinted differentially me...

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Detalles Bibliográficos
Autores principales: Watanabe, Hidetaka, Higashimoto, Ken, Miyake, Noriko, Morita, Sumiyo, Horii, Takuro, Kimura, Mika, Suzuki, Takayuki, Maeda, Toshiyuki, Hidaka, Hidenori, Aoki, Saori, Yatsuki, Hitomi, Okamoto, Nobuhiko, Uemura, Tetsuji, Hatada, Izuho, Matsumoto, Naomichi, Soejima, Hidenobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973060/
https://www.ncbi.nlm.nih.gov/pubmed/31914674
http://dx.doi.org/10.1096/fj.201901757R

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