Cargando…

Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation through SREBP1

OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is among the most common chronic liver diseases. However, the pathogenesis of NAFLD is not still unclear. This study aims at evaluating the role of zinc finger and BTB domain-containing 7A (ZBTB7A) in NAFLD. METHODS: Western blotting, real-time rev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Jing-ping, Ren, Yan-dan, Xu, Qin-yu, Song, Yang, Zhou, Fei, Chen, Mei-Ya, Liu, Jing-jing, Chen, Li-Gang, Pan, Jin-Shui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973189/ https://www.ncbi.nlm.nih.gov/pubmed/31998789 http://dx.doi.org/10.1155/2020/4087928

Ejemplares similares

Loss of hepatic FTCD promotes lipid accumulation and hepatocarcinogenesis by upregulating PPARγ and SREBP2
por: Wang, Siying, et al.
Publicado: (2023)

ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma
por: Ferrarese, Roberto, et al.
Publicado: (2022)

Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice
por: Wang, Chun-Mei, et al.
Publicado: (2016)

miR-106b regulates the 5-fluorouracil resistance by targeting Zbtb7a in cholangiocarcinoma
por: Jiao, Dechao, et al.
Publicado: (2017)

Targeting SREBP1 chemosensitizes colorectal cancer cells to gemcitabine by caspase-7 upregulation
por: Shen, Wenlong, et al.
Publicado: (2019)

Upregulation of MicroRNA-4262 Targets Kaiso (ZBTB33) to Inhibit the Proliferation and EMT of Cervical Cancer Cells
por: Feng, Jing
Publicado: (2018)

HBV DNA integrates into upregulated ZBTB20 in patients with hepatocellular carcinoma
por: He, Zebao, et al.
Publicado: (2020)

Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia
por: Ren, Ren, et al.
Publicado: (2023)

BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27
por: He, Jin, et al.
Publicado: (2020)

ZBTB7A functioned as an oncogene in colorectal cancer
por: Wang, Li, et al.
Publicado: (2020)

Negative feedback loop between ZBTB7A and TGF-β in breast cancer
por: Shen, Yingying, et al.
Publicado: (2017)

Circular RNA-ZBTB44 regulates the development of choroidal neovascularization
por: Zhou, Rong-mei, et al.
Publicado: (2020)

SREBP activation contributes to fatty acid accumulations in necroptosis
por: Lu, Daniel, et al.
Publicado: (2023)

The elevation of miR-185-5p alleviates high-fat diet-induced atherosclerosis and lipid accumulation in vivo and in vitro via SREBP2 activation
por: Tan, Wenyun, et al.
Publicado: (2022)

ZBTB20 in Nociceptive Neurons of the Trigeminal Ganglia Regulates Pruritus
por: Jia, Xin, et al.
Publicado: (2021)

SREBP1-Induced Glutamine Synthetase Triggers a Feedforward Loop to Upregulate SREBP1 through Sp1 O-GlcNAcylation and Augments Lipid Droplet Formation in Cancer Cells
por: Jhu, Jin-Wei, et al.
Publicado: (2021)

Gemfibrozil reduces lipid accumulation in SMMC-7721 cells via the involvement of PPARα and SREBP1
por: Zhang, Xiaonan, et al.
Publicado: (2019)

HCBP6 upregulates human SREBP1c expression by binding to C/EBPβ-binding site in the SREBP1c promoter
por: Yang, Xueliang, et al.
Publicado: (2018)

Zbtb38 is a novel target for spinal cord injury
por: Cai, Yafei, et al.
Publicado: (2017)

Epigenetic DNA methylation of Zbtb7b regulates the population of double-positive CD4(+)CD8(+) T cells in ulcerative colitis
por: Xu, Hao-ming, et al.
Publicado: (2022)

Lipid-cell cycle nexus: SREBP regulates microRNAs targeting Fbxw7
por: Esquejo, Ryan M, et al.
Publicado: (2014)

Lactobacillus plantarum Ameliorates High-Carbohydrate Diet-Induced Hepatic Lipid Accumulation and Oxidative Stress by Upregulating Uridine Synthesis
por: Xu, Rong, et al.
Publicado: (2022)

Structural basis for human ZBTB7A action at the fetal globin promoter
por: Yang, Yang, et al.
Publicado: (2021)

Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish
por: Cao, Xiufei, et al.
Publicado: (2022)

TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway
por: Yin, F, et al.
Publicado: (2017)

SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1β pathway: SREBP2 Inhibitor sensitizes HCC to lenvatinib
por: Fan, Minghao, et al.
Publicado: (2023)

ZBTB7 HapMap in a worldwide population study
por: Salas, A, et al.
Publicado: (2005)

The multi-faceted functioning portrait of LRF/ZBTB7A
por: Constantinou, Caterina, et al.
Publicado: (2019)

The prognostic and immunological effects of ZBTB7C across cancers: friend or foe?
por: Chen, Xuenuo, et al.
Publicado: (2021)

Global mapping of ZBTB7A transcription factor binding sites in HepG2 cells
por: Zu, Xuyu, et al.
Publicado: (2010)

CircZBTB46 Protects Acute Myeloid Leukemia Cells from Ferroptotic Cell Death by Upregulating SCD
por: Long, Fei, et al.
Publicado: (2023)

Magma Seawater Inhibits Hepatic Lipid Accumulation through Suppression of Lipogenic Enzymes Regulated by SREBPs in Thioacetamide-Injected Rats
por: Woo, Minji, et al.
Publicado: (2019)

Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models
por: Zhang, Youying, et al.
Publicado: (2017)

Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System
por: Zheng, Zu-Guo, et al.
Publicado: (2019)

ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration
por: Zhang, Hai, et al.
Publicado: (2018)

The ‘Pokemon’ (ZBTB7) Gene: No Evidence of Association with Sporadic Breast Cancer
por: Salas, Antonio, et al.
Publicado: (2008)

High-density screening of the Zbtb7 gene in breast cancer patients
por: Salas, A, et al.
Publicado: (2005)

ZBTB7A as a novel vulnerability in neuroendocrine prostate cancer
por: Bae, Song Yi, et al.
Publicado: (2023)

Reduced miR-200b and miR-200c expression contributes to abnormal hepatic lipid accumulation by stimulating JUN expression and activating the transcription of srebp1
por: Guo, Jun, et al.
Publicado: (2016)

Genistein upregulates LDLR levels via JNK-mediated activation of SREBP-2
por: Kartawijaya, Medicia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_tb2kthcc2b0afvhc43rq4ah698