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EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2
Proline‐rich tyrosine kinase 2 (Pyk2) is a member of focal adhesion kinase (FAK) non‐receptor tyrosine kinase family and has been found to promote cancer cell survival, proliferation, migration, invasion, and metastasis. Pyk2 takes part in different carcinogenic signaling pathways to promote cancer...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973235/ https://www.ncbi.nlm.nih.gov/pubmed/31368612 http://dx.doi.org/10.1002/cbin.11209 |
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author | Shen, Ting Guo, Qiang |
author_facet | Shen, Ting Guo, Qiang |
author_sort | Shen, Ting |
collection | PubMed |
description | Proline‐rich tyrosine kinase 2 (Pyk2) is a member of focal adhesion kinase (FAK) non‐receptor tyrosine kinase family and has been found to promote cancer cell survival, proliferation, migration, invasion, and metastasis. Pyk2 takes part in different carcinogenic signaling pathways to promote cancer progression, including epidermal growth factor receptor (EGFR) signaling pathway. EGFR signaling pathway is a traditional carcinogenic signaling pathway, which plays a critical role in tumorigenesis and tumor progression. FAK inhibitors have been reported to fail to get the ideal anti‐cancer outcomes because of activation of EGFR signaling pathway. Better understanding of Pyk2 downstream targets and interconnectivity between Pyk2 and carcinogenic EGFR signaling pathway will help finding more effective targets for clinical anti‐cancer combination therapies. Thus, the interconnectivity between Pyk2 and EGFR signaling pathway, which regulates tumor development and metastasis, needs to be elucidated. In this review, we summarized the downstream targets of Pyk2 in cancers, focused on the connection between Pyk2 and EGFR signaling pathway in different cancer types, and provided a new overview of the roles of Pyk2 in EGFR signaling pathway and cancer development. |
format | Online Article Text |
id | pubmed-6973235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69732352020-01-27 EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2 Shen, Ting Guo, Qiang Cell Biol Int Reviews Proline‐rich tyrosine kinase 2 (Pyk2) is a member of focal adhesion kinase (FAK) non‐receptor tyrosine kinase family and has been found to promote cancer cell survival, proliferation, migration, invasion, and metastasis. Pyk2 takes part in different carcinogenic signaling pathways to promote cancer progression, including epidermal growth factor receptor (EGFR) signaling pathway. EGFR signaling pathway is a traditional carcinogenic signaling pathway, which plays a critical role in tumorigenesis and tumor progression. FAK inhibitors have been reported to fail to get the ideal anti‐cancer outcomes because of activation of EGFR signaling pathway. Better understanding of Pyk2 downstream targets and interconnectivity between Pyk2 and carcinogenic EGFR signaling pathway will help finding more effective targets for clinical anti‐cancer combination therapies. Thus, the interconnectivity between Pyk2 and EGFR signaling pathway, which regulates tumor development and metastasis, needs to be elucidated. In this review, we summarized the downstream targets of Pyk2 in cancers, focused on the connection between Pyk2 and EGFR signaling pathway in different cancer types, and provided a new overview of the roles of Pyk2 in EGFR signaling pathway and cancer development. John Wiley and Sons Inc. 2019-08-11 2020-01 /pmc/articles/PMC6973235/ /pubmed/31368612 http://dx.doi.org/10.1002/cbin.11209 Text en © 2019 The Authors. Cell Biology International published by John Wiley & Sons Ltd on behalf of International Federation of Cell Biology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Shen, Ting Guo, Qiang EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2 |
title | EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2 |
title_full | EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2 |
title_fullStr | EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2 |
title_full_unstemmed | EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2 |
title_short | EGFR signaling pathway occupies an important position in cancer‐related downstream signaling pathways of Pyk2 |
title_sort | egfr signaling pathway occupies an important position in cancer‐related downstream signaling pathways of pyk2 |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973235/ https://www.ncbi.nlm.nih.gov/pubmed/31368612 http://dx.doi.org/10.1002/cbin.11209 |
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