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Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119
The acyl‐binding UNC119 proteins mediate the activation and transport of various N‐myristoylated proteins. In particular, UNC119a plays a crucial role in the completion of cytokinesis. Herein, we report the use of a lipidated peptide originating from the UNC119 binding partner Gnat1 as the basis for...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973269/ https://www.ncbi.nlm.nih.gov/pubmed/31680402 http://dx.doi.org/10.1002/cbic.201900615 |
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| author | Cromm, Philipp M. Adihou, Hélène Kapoor, Shobhna Vazquez‐Chantada, Mercedes Davey, Paul Longmire, David Hennes, Elisabeth Hofer, Walter Küchler, Philipp Chiarparin, Elisabetta Waldmann, Herbert Grossmann, Tom N. |
| author_facet | Cromm, Philipp M. Adihou, Hélène Kapoor, Shobhna Vazquez‐Chantada, Mercedes Davey, Paul Longmire, David Hennes, Elisabeth Hofer, Walter Küchler, Philipp Chiarparin, Elisabetta Waldmann, Herbert Grossmann, Tom N. |
| author_sort | Cromm, Philipp M. |
| collection | PubMed |
| description | The acyl‐binding UNC119 proteins mediate the activation and transport of various N‐myristoylated proteins. In particular, UNC119a plays a crucial role in the completion of cytokinesis. Herein, we report the use of a lipidated peptide originating from the UNC119 binding partner Gnat1 as the basis for the design of lipidated, stabilized α‐helical peptides that target UNC119a. By using the hydrocarbon peptide‐stapling approach, cell‐permeable binders of UNC119a were generated that induced the accumulation of cytokinetic and binucleated cells; this suggests UNC119a as a potential target for the inhibition of cytokinesis. |
| format | Online Article Text |
| id | pubmed-6973269 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-69732692020-01-28 Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119 Cromm, Philipp M. Adihou, Hélène Kapoor, Shobhna Vazquez‐Chantada, Mercedes Davey, Paul Longmire, David Hennes, Elisabeth Hofer, Walter Küchler, Philipp Chiarparin, Elisabetta Waldmann, Herbert Grossmann, Tom N. Chembiochem Communications The acyl‐binding UNC119 proteins mediate the activation and transport of various N‐myristoylated proteins. In particular, UNC119a plays a crucial role in the completion of cytokinesis. Herein, we report the use of a lipidated peptide originating from the UNC119 binding partner Gnat1 as the basis for the design of lipidated, stabilized α‐helical peptides that target UNC119a. By using the hydrocarbon peptide‐stapling approach, cell‐permeable binders of UNC119a were generated that induced the accumulation of cytokinetic and binucleated cells; this suggests UNC119a as a potential target for the inhibition of cytokinesis. John Wiley and Sons Inc. 2019-11-19 2019-12-13 /pmc/articles/PMC6973269/ /pubmed/31680402 http://dx.doi.org/10.1002/cbic.201900615 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Communications Cromm, Philipp M. Adihou, Hélène Kapoor, Shobhna Vazquez‐Chantada, Mercedes Davey, Paul Longmire, David Hennes, Elisabeth Hofer, Walter Küchler, Philipp Chiarparin, Elisabetta Waldmann, Herbert Grossmann, Tom N. Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119 |
| title | Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119 |
| title_full | Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119 |
| title_fullStr | Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119 |
| title_full_unstemmed | Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119 |
| title_short | Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119 |
| title_sort | lipidated stapled peptides targeting the acyl binding protein unc119 |
| topic | Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973269/ https://www.ncbi.nlm.nih.gov/pubmed/31680402 http://dx.doi.org/10.1002/cbic.201900615 |
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