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Cascade Cross‐Coupling of Dienes: Photoredox and Nickel Dual Catalysis

Chemical transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex molecules dramatically. Herein, we disclose an unprecedented and efficient method for the cross‐coupling of radical precursors, dienes, and electrophilic coupling...

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Detalles Bibliográficos
Autores principales: Huang, Long, Zhu, Chen, Yi, Liang, Yue, Huifeng, Kancherla, Rajesh, Rueping, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973272/
https://www.ncbi.nlm.nih.gov/pubmed/31778289
http://dx.doi.org/10.1002/anie.201911109
Descripción
Sumario:Chemical transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex molecules dramatically. Herein, we disclose an unprecedented and efficient method for the cross‐coupling of radical precursors, dienes, and electrophilic coupling partners via a photoredox‐ and nickel‐enabled cascade cross‐coupling process. The cascade reaction furnishes a diverse array of saturated carbo‐ and heterocyclic scaffolds, thus providing access to a quick gain in C−C bond saturation.