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Discovery and characterization of single-domain antibodies for polymeric Ig receptor-mediated mucosal delivery of biologics

Mucosal immunity is dominated by secretory IgA and IgM, although these are less favorable compared to IgG molecules for therapeutic development. Polymeric IgA and IgM are actively transported across the epithelial barrier via engagement of the polymeric Ig receptor (pIgR), but IgG molecules lack a l...

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Detalles Bibliográficos
Autores principales:	Maruthachalam, Bharathikumar Vellalore, Zwolak, Adam, Lin-Schmidt, Xiefan, Keough, Edward, Tamot, Ninkka, Venkataramani, Sathya, Geist, Brian, Singh, Sanjaya, Ganesan, Rajkumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973331/ https://www.ncbi.nlm.nih.gov/pubmed/31906797 http://dx.doi.org/10.1080/19420862.2019.1708030

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