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Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site

LINGO-1 is a membrane protein of the central nervous system (CNS) that suppresses myelination of axons. Preclinical studies have revealed that blockade of LINGO-1 function leads to CNS repair in demyelinating animal models. The anti-LINGO-1 antibody Li81 (opicinumab), which blocks LINGO-1 function a...

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Detalles Bibliográficos
Autores principales:	Hanf, Karl J. M., Arndt, Joseph W., Liu, YuTing, Gong, Bang Jian, Rushe, Mia, Sopko, Richelle, Massol, Ramiro, Smith, Benjamin, Gao, Yan, Dalkilic-Liddle, Isin, Lee, Xinhua, Mojta, Shanell, Shao, Zhaohui, Mi, Sha, Pepinsky, R. Blake
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973334/ https://www.ncbi.nlm.nih.gov/pubmed/31928294 http://dx.doi.org/10.1080/19420862.2020.1713648

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