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Sexual transmission of Hepatitis C Virus infection in a heterosexual population: A systematic review

Background: Hepatitis C virus (HCV) infection is an important cause of liver disease worldwide. Identification of risk factors can guide screening and prevention. Sexual transmission in monogamous heterosexual relationships is rare but it is uncertain which sexual behaviours are linked to HCV transm...

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Autores principales: Wuytack, Francesca, Lutje, Vittoria, Jakobsen, Janus Christian, Weiss, Karl Heinz, Flanagan, Paula, Gethin, Georgina, Murphy, Louise, Smyth, Siobhan, Devane, Declan, Smith, Valerie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973529/
https://www.ncbi.nlm.nih.gov/pubmed/32002504
http://dx.doi.org/10.12688/hrbopenres.12791.1
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author Wuytack, Francesca
Lutje, Vittoria
Jakobsen, Janus Christian
Weiss, Karl Heinz
Flanagan, Paula
Gethin, Georgina
Murphy, Louise
Smyth, Siobhan
Devane, Declan
Smith, Valerie
author_facet Wuytack, Francesca
Lutje, Vittoria
Jakobsen, Janus Christian
Weiss, Karl Heinz
Flanagan, Paula
Gethin, Georgina
Murphy, Louise
Smyth, Siobhan
Devane, Declan
Smith, Valerie
author_sort Wuytack, Francesca
collection PubMed
description Background: Hepatitis C virus (HCV) infection is an important cause of liver disease worldwide. Identification of risk factors can guide screening and prevention. Sexual transmission in monogamous heterosexual relationships is rare but it is uncertain which sexual behaviours are linked to HCV transmission. This review aimed to determine risk factors for sexual HCV transmission in heterosexuals in low HCV prevalence countries (PROSPERO registration CRD42016051099). Methods: We searched Medline, Embase, Science Citation Index-Expanded, Social Sciences Citation index, Conference proceedings (Web of Science), CINAHL, Scopus, LILACS, PubMed, and grey literature (04/11/2016). We included studies published in/after the year 2000 that examined sexual risk factors for HCV infection, other than interspousal transmission, in heterosexual adults (≥18 years). We excluded prisoners, people who inject drugs (PWIDs), people co-infected with HIV or from high prevalence countries. Two reviewers completed study selection, data extraction, risk of bias and quality of evidence assessment (GRADE) independently. Meta-analysis could not be conducted. Results: Eight studies were included, examining seven factors (multiple sex partners, receiving/providing sex commercially, PWID partner, and unprotected vaginal, oral, anal sex). None were significant, except the evidence for the factor having a PWID partner was conflicting. Conclusions: We are uncertain about the results due to the very low quality of evidence (GRADE). A more liberal approach to review inclusion criteria might be useful in further identifying factors associated with an increased risk of sexual transmission of HCV infection in a heterosexual population. However, caution should be applied to avoid the impact of confounders on the findings.
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spelling pubmed-69735292020-01-29 Sexual transmission of Hepatitis C Virus infection in a heterosexual population: A systematic review Wuytack, Francesca Lutje, Vittoria Jakobsen, Janus Christian Weiss, Karl Heinz Flanagan, Paula Gethin, Georgina Murphy, Louise Smyth, Siobhan Devane, Declan Smith, Valerie HRB Open Res Systematic Review Background: Hepatitis C virus (HCV) infection is an important cause of liver disease worldwide. Identification of risk factors can guide screening and prevention. Sexual transmission in monogamous heterosexual relationships is rare but it is uncertain which sexual behaviours are linked to HCV transmission. This review aimed to determine risk factors for sexual HCV transmission in heterosexuals in low HCV prevalence countries (PROSPERO registration CRD42016051099). Methods: We searched Medline, Embase, Science Citation Index-Expanded, Social Sciences Citation index, Conference proceedings (Web of Science), CINAHL, Scopus, LILACS, PubMed, and grey literature (04/11/2016). We included studies published in/after the year 2000 that examined sexual risk factors for HCV infection, other than interspousal transmission, in heterosexual adults (≥18 years). We excluded prisoners, people who inject drugs (PWIDs), people co-infected with HIV or from high prevalence countries. Two reviewers completed study selection, data extraction, risk of bias and quality of evidence assessment (GRADE) independently. Meta-analysis could not be conducted. Results: Eight studies were included, examining seven factors (multiple sex partners, receiving/providing sex commercially, PWID partner, and unprotected vaginal, oral, anal sex). None were significant, except the evidence for the factor having a PWID partner was conflicting. Conclusions: We are uncertain about the results due to the very low quality of evidence (GRADE). A more liberal approach to review inclusion criteria might be useful in further identifying factors associated with an increased risk of sexual transmission of HCV infection in a heterosexual population. However, caution should be applied to avoid the impact of confounders on the findings. F1000 Research Limited 2018-03-08 /pmc/articles/PMC6973529/ /pubmed/32002504 http://dx.doi.org/10.12688/hrbopenres.12791.1 Text en Copyright: © 2018 Wuytack F et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Systematic Review
Wuytack, Francesca
Lutje, Vittoria
Jakobsen, Janus Christian
Weiss, Karl Heinz
Flanagan, Paula
Gethin, Georgina
Murphy, Louise
Smyth, Siobhan
Devane, Declan
Smith, Valerie
Sexual transmission of Hepatitis C Virus infection in a heterosexual population: A systematic review
title Sexual transmission of Hepatitis C Virus infection in a heterosexual population: A systematic review
title_full Sexual transmission of Hepatitis C Virus infection in a heterosexual population: A systematic review
title_fullStr Sexual transmission of Hepatitis C Virus infection in a heterosexual population: A systematic review
title_full_unstemmed Sexual transmission of Hepatitis C Virus infection in a heterosexual population: A systematic review
title_short Sexual transmission of Hepatitis C Virus infection in a heterosexual population: A systematic review
title_sort sexual transmission of hepatitis c virus infection in a heterosexual population: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973529/
https://www.ncbi.nlm.nih.gov/pubmed/32002504
http://dx.doi.org/10.12688/hrbopenres.12791.1
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