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Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients

BACKGROUND: Hyperglycemia, insulin resistance, and hyperinsulinemia represent important pathophysiological components of the prediabetic stage that result in arteriosclerosis and increased arterial stiffness. We sought to compare the aortic distensibility (AD) assessed by cardiac magnetic resonance...

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Autores principales: A. Razik, Nady, Kishk, Y. T., Bakheet, Madeeha Younis, Nous, Mina, Abdel Ghany, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973669/
https://www.ncbi.nlm.nih.gov/pubmed/31965377
http://dx.doi.org/10.1186/s43044-020-0040-0
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author A. Razik, Nady
Kishk, Y. T.
Bakheet, Madeeha Younis
Nous, Mina
Abdel Ghany, Mohamed
author_facet A. Razik, Nady
Kishk, Y. T.
Bakheet, Madeeha Younis
Nous, Mina
Abdel Ghany, Mohamed
author_sort A. Razik, Nady
collection PubMed
description BACKGROUND: Hyperglycemia, insulin resistance, and hyperinsulinemia represent important pathophysiological components of the prediabetic stage that result in arteriosclerosis and increased arterial stiffness. We sought to compare the aortic distensibility (AD) assessed by cardiac magnetic resonance (CMR) in prediabetic patients presenting with chronic coronary artery disease (CCAD) versus patients with normal HbA1C. Ninety-eight patients with CCAD were recruited. All patients were screened for HbA1C levels and then underwent a CMR study to assess AD of the aortic root and the ascending and descending thoracic aorta. Patients were classified into two groups: 52 prediabetic (HbA1C 5.7–6.4%) (study group) and 46 with normal glycemic status (HbA1C < 5.7%) (control group). RESULTS: AD values at the aortic root (AR) (13.93 ± 5.17 vs 34.3 ± 9.65 Kpa(-1) × 10(-3)), ascending aorta (AA) (13.17 ± 4.81 vs 28.1 ± 8.33 Kpa(-1) × 10(-3)), and descending thoracic aorta (DA) (18.12 ± 4.34 vs 33.68 ± 7.57 Kpa(-1) × 10(-3)) were significantly lower in the study group than in the control group (P value for all was < 0.001). Twenty-eight patients fulfilled the criteria for metabolic syndrome, and in those patients, AD was significantly lower than in those without metabolic syndrome. Aortic distensibility at the AR, AA, and DA had strong significant negative correlations with the level of glycosylated hemoglobin (AA, AR, DA; r − 0.66, − 0.68, − 0.58, respectively) (P < 0.001). CONCLUSION: AD values at different points (AR, AA, and DA) were significantly lower in prediabetic and metabolic syndrome patients than in controls. These values also showed a significant negative correlation with the levels of HBA1C.
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spelling pubmed-69736692020-02-03 Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients A. Razik, Nady Kishk, Y. T. Bakheet, Madeeha Younis Nous, Mina Abdel Ghany, Mohamed Egypt Heart J Research BACKGROUND: Hyperglycemia, insulin resistance, and hyperinsulinemia represent important pathophysiological components of the prediabetic stage that result in arteriosclerosis and increased arterial stiffness. We sought to compare the aortic distensibility (AD) assessed by cardiac magnetic resonance (CMR) in prediabetic patients presenting with chronic coronary artery disease (CCAD) versus patients with normal HbA1C. Ninety-eight patients with CCAD were recruited. All patients were screened for HbA1C levels and then underwent a CMR study to assess AD of the aortic root and the ascending and descending thoracic aorta. Patients were classified into two groups: 52 prediabetic (HbA1C 5.7–6.4%) (study group) and 46 with normal glycemic status (HbA1C < 5.7%) (control group). RESULTS: AD values at the aortic root (AR) (13.93 ± 5.17 vs 34.3 ± 9.65 Kpa(-1) × 10(-3)), ascending aorta (AA) (13.17 ± 4.81 vs 28.1 ± 8.33 Kpa(-1) × 10(-3)), and descending thoracic aorta (DA) (18.12 ± 4.34 vs 33.68 ± 7.57 Kpa(-1) × 10(-3)) were significantly lower in the study group than in the control group (P value for all was < 0.001). Twenty-eight patients fulfilled the criteria for metabolic syndrome, and in those patients, AD was significantly lower than in those without metabolic syndrome. Aortic distensibility at the AR, AA, and DA had strong significant negative correlations with the level of glycosylated hemoglobin (AA, AR, DA; r − 0.66, − 0.68, − 0.58, respectively) (P < 0.001). CONCLUSION: AD values at different points (AR, AA, and DA) were significantly lower in prediabetic and metabolic syndrome patients than in controls. These values also showed a significant negative correlation with the levels of HBA1C. Springer Berlin Heidelberg 2020-01-21 /pmc/articles/PMC6973669/ /pubmed/31965377 http://dx.doi.org/10.1186/s43044-020-0040-0 Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
A. Razik, Nady
Kishk, Y. T.
Bakheet, Madeeha Younis
Nous, Mina
Abdel Ghany, Mohamed
Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients
title Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients
title_full Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients
title_fullStr Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients
title_full_unstemmed Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients
title_short Cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients
title_sort cardiac magnetic resonance assessment of aortic distensibility in prediabetic patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973669/
https://www.ncbi.nlm.nih.gov/pubmed/31965377
http://dx.doi.org/10.1186/s43044-020-0040-0
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