Challenges associated with homologous directed repair using CRISPR-Cas9 and TALEN to edit the DMD genetic mutation in canine Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene that abolish the expression of dystrophin protein. Dogs with the genetic homologue, golden retriever muscular dystrophy dog (GRMD), have a splice site mutation that leads to skipping of exon 7 and a stop codon in the DMD transc...

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Detalles Bibliográficos
Autores principales: Mata López, Sara, Balog-Alvarez, Cynthia, Vitha, Stanislav, Bettis, Amanda K., Canessa, Emily H., Kornegay, Joe N., Nghiem, Peter P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974172/
https://www.ncbi.nlm.nih.gov/pubmed/31961902
http://dx.doi.org/10.1371/journal.pone.0228072

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