Cargando…

Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy

Cells sensing infection produce Type I interferons (IFN-I) to stimulate Interferon Stimulated Genes (ISGs) that confer resistance to viruses. During lympho-hematogenous spread of the mouse pathogen ectromelia virus (ECTV), the adaptor STING and the transcription factor IRF7 are required for IFN-I an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wong, Eric B., Montoya, Brian, Ferez, Maria, Stotesbury, Colby, Sigal, Luis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974301/ https://www.ncbi.nlm.nih.gov/pubmed/31877196 http://dx.doi.org/10.1371/journal.ppat.1008239

Ejemplares similares

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
por: Li, Tiejun, et al.
Publicado: (2016)

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
por: Li, Tuo, et al.
Publicado: (2018)

The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism
por: Bai, Juli, et al.
Publicado: (2019)

Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signaling
por: Eaglesham, James B., et al.
Publicado: (2019)

cGAS Restricts PRRSV Replication by Sensing the mtDNA to Increase the cGAMP Activity
por: Liu, Xiao-Na, et al.
Publicado: (2022)

Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis?
por: Elmanfi, Samira, et al.
Publicado: (2021)

cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila
por: Slavik, Kailey M., et al.
Publicado: (2021)

cGAMP the travelling messenger
por: Blest, Henry T. W., et al.
Publicado: (2023)

Small molecule inhibition of human cGAS reduces total cGAMP output and cytokine expression in cells
por: Wiser, Caroline, et al.
Publicado: (2020)

Bacterial cGAS-like enzymes produce 2′,3′-cGAMP to activate an ion channel that restricts phage replication
por: Tak, Uday, et al.
Publicado: (2023)

Self-assembled cGAMP-STINGΔTM signaling complex as a bioinspired platform for cGAMP delivery
por: He, Yanpu, et al.
Publicado: (2020)

The Signaling Pathway That cGAMP Riboswitches Found: Analysis and Application of Riboswitches to Study cGAMP Signaling in Geobacter sulfurreducens
por: Tan, Zhesen, et al.
Publicado: (2022)

Human SLC46A2 Is the Dominant cGAMP Importer in Extracellular cGAMP-Sensing Macrophages and Monocytes
por: Cordova, Anthony F., et al.
Publicado: (2021)

cGAMP: A tale of two signals
por: Kuriakose, Teneema, et al.
Publicado: (2017)

Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict
por: Eaglesham, James B, et al.
Publicado: (2020)

Tumor-Derived cGAMP Regulates Activation of the Vasculature
por: Campisi, Marco, et al.
Publicado: (2020)

Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation
por: Lai, Junzhong, et al.
Publicado: (2020)

A noncanonical function of cGAMP in inflammasome priming and activation
por: Swanson, Karen V., et al.
Publicado: (2017)

The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus
por: Cheng, Wen-Yu, et al.
Publicado: (2018)

Effects on Metabolism in Astrocytes Caused by cGAMP, Which Imitates the Initial Stage of Brain Metastasis
por: Okawa, Toya, et al.
Publicado: (2021)

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses
por: Pépin, Geneviève, et al.
Publicado: (2020)

Novel Poxin Stable cGAMP‐Derivatives Are Remarkable STING Agonists
por: Stazzoni, Samuele, et al.
Publicado: (2022)

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP
por: Jønsson, K. L., et al.
Publicado: (2017)

Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells
por: Melo-Silva, Carolina R., et al.
Publicado: (2021)

Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer
por: Chen, Qing, et al.
Publicado: (2016)

Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
por: Kato, Kazuki, et al.
Publicado: (2018)

Poxvirus cGAMP nucleases: Clues and mysteries from a stolen gene
por: Maluquer de Motes, Carlos
Publicado: (2021)

Inclusion of cGAMP within virus‐like particle vaccines enhances their immunogenicity
por: Chauveau, Lise, et al.
Publicado: (2021)

A Multi-Enzyme Cascade Reaction for the Production of 2′3′-cGAMP
por: Becker, Martin, et al.
Publicado: (2021)

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway
por: Wang, Songnan, et al.
Publicado: (2023)

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of non-hydrolyzable analogs
por: Li, Lingyin, et al.
Publicado: (2014)

Protocol for identification and validation of 2′3′-cGAMP-binding proteins by photoaffinity probes
por: Hou, Yingjie, et al.
Publicado: (2022)

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling
por: Gentili, Matteo, et al.
Publicado: (2023)

An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP
por: Li, Xiaobo, et al.
Publicado: (2022)

ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling
por: Carozza, Jacqueline A., et al.
Publicado: (2022)

Sensing Cytosolic DNA Lowers Blood Pressure by Direct cGAMP-Dependent PKGI Activation
por: Su, Jie, et al.
Publicado: (2023)

Improving poxvirus-mediated antitumor immune responses by deleting viral cGAMP-specific nuclease
por: Riederer, Stephanie, et al.
Publicado: (2023)

cGAMP Promotes Germinal Center Formation and Production of IgA in Nasal-Associated Lymphoid Tissue
por: Takaki, Hiromi, et al.
Publicado: (2017)

Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency
por: Jütte, Bianca B., et al.
Publicado: (2021)

Proteomic analysis of RAW macrophages treated with cGAMP or c-di-GMP reveals differentially activated cellular pathways
por: Sooreshjani, Moloud Aflaki, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_d6qcnu49aqmlrpup0k7sqcd637