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Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy

Cells sensing infection produce Type I interferons (IFN-I) to stimulate Interferon Stimulated Genes (ISGs) that confer resistance to viruses. During lympho-hematogenous spread of the mouse pathogen ectromelia virus (ECTV), the adaptor STING and the transcription factor IRF7 are required for IFN-I an...

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Detalles Bibliográficos
Autores principales:	Wong, Eric B., Montoya, Brian, Ferez, Maria, Stotesbury, Colby, Sigal, Luis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974301/ https://www.ncbi.nlm.nih.gov/pubmed/31877196 http://dx.doi.org/10.1371/journal.ppat.1008239

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